Synergin gamma

SYNRG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MX7
Identifiers
Aliases	SYNRG, AP1GBP1, SYNG, synergin, gamma, synergin gamma
External IDs	OMIM: 607291; MGI: 1354742; HomoloGene: 105680; GeneCards: SYNRG; OMA:SYNRG - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q12 Start 37,514,807 bp[1] End 37,609,472 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 C Start 83,855,254 bp[2] End 83,935,404 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cells tonsil epithelium of colon sural nerve lymph node islet of Langerhans granulocyte appendix corpus callosum ganglionic eminence Top expressed in zygote spermatocyte spermatid muscle of thigh dentate gyrus of hippocampal formation granule cell secondary oocyte granulocyte neural layer of retina ventricular zone superior frontal gyrus More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component cytoplasm AP-1 adaptor complex Golgi apparatus membrane Biological process protein transport intracellular protein transport endocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11276 217030 Ensembl ENSG00000275066 ENSG00000274047 ENSMUSG00000034940 UniProt Q9UMZ2 Q5SV85 RefSeq (mRNA) NM_001163544 NM_001163545 NM_001163546 NM_001163547 NM_007247 NM_080550 NM_198882 NM_001115009 NM_194341 RefSeq (protein) NP_001157016 NP_001157017 NP_001157018 NP_001157019 NP_009178 NP_542117 NP_942583 NP_919322 NP_001392038 NP_001392041 NP_001392042 NP_001392044 NP_001392045 NP_001392047 NP_001392050 NP_001392051 NP_001392052 Location (UCSC) Chr 17: 37.51 – 37.61 Mb Chr 11: 83.86 – 83.94 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Synergin gamma also known as AP1 subunit gamma-binding protein 1 (AP1GBP1) is a protein that in humans is encoded by the SYNRG gene.[5][6]

Function

This gene encodes a protein that interacts with the gamma subunit of AP1 clathrin-adaptor complex. The AP1 complex is located at the trans-Golgi network and associates specific proteins with clathrin-coated vesicles. This encoded protein may act to connect the AP1 complex to other proteins. Alternatively spliced transcript variants that encode different isoforms have been described for this gene.[6]

Interactions

AP1GBP1 has been shown to interact with AP1G1[7][8] and SCAMP1.[9]

References

1. ENSG00000274047 GRCh38: Ensembl release 89: ENSG00000275066, ENSG00000274047 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034940 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Page LJ, Sowerby PJ, Lui WW, Robinson MS (October 1999). "Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin". J. Cell Biol. 146 (5): 993–1004. doi:10.1083/jcb.146.5.993. PMC 2169493. PMID 10477754.
6. "Entrez Gene: AP1GBP1 AP1 gamma subunit binding protein 1".
7. Nogi T, Shiba Y, Kawasaki M, Shiba T, Matsugaki N, Igarashi N, Suzuki M, Kato R, Takatsu H, Nakayama K, Wakatsuki S (July 2002). "Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain". Nat. Struct. Biol. 9 (7): 527–31. doi:10.1038/nsb808. PMID 12042876. S2CID 42630285.
8. Takatsu H, Yoshino K, Nakayama K (May 2000). "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochem. Biophys. Res. Commun. 271 (3): 719–25. doi:10.1006/bbrc.2000.2700. PMID 10814529.
9. Fernández-Chacón R, Achiriloaie M, Janz R, Albanesi JP, Südhof TC (April 2000). "SCAMP1 function in endocytosis". J. Biol. Chem. 275 (17): 12752–6. doi:10.1074/jbc.275.17.12752. PMID 10777571.

Further reading

• Peyrard M, Parveneh S, Lagercrantz S, Ekman M, Fransson I, Sahlén S, Dumanski JP (1998). "Cloning, expression pattern, and chromosomal assignment to 16q23 of the human gamma-adaptin gene (ADTG)". Genomics. 50 (2): 275–80. doi:10.1006/geno.1998.5289. PMID 9653655.
• Hirst J, Lui WW, Bright NA, Totty N, Seaman MN, Robinson MS (2000). "A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome". J. Cell Biol. 149 (1): 67–80. doi:10.1083/jcb.149.1.67. PMC 2175106. PMID 10747088.
• Fernández-Chacón R, Achiriloaie M, Janz R, Albanesi JP, Südhof TC (2000). "SCAMP1 function in endocytosis". J. Biol. Chem. 275 (17): 12752–6. doi:10.1074/jbc.275.17.12752. PMID 10777571.
• Takatsu H, Yoshino K, Nakayama K (2000). "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochem. Biophys. Res. Commun. 271 (3): 719–25. doi:10.1006/bbrc.2000.2700. PMID 10814529.
• Nogi T, Shiba Y, Kawasaki M, Shiba T, Matsugaki N, Igarashi N, Suzuki M, Kato R, Takatsu H, Nakayama K, Wakatsuki S (2002). "Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain". Nat. Struct. Biol. 9 (7): 527–31. doi:10.1038/nsb808. PMID 12042876. S2CID 42630285.
• Kent HM, McMahon HT, Evans PR, Benmerah A, Owen DJ (2002). "Gamma-adaptin appendage domain: structure and binding site for Eps15 and gamma-synergin". Structure. 10 (8): 1139–48. doi:10.1016/S0969-2126(02)00801-8. PMID 12176391.
• Mills IG, Praefcke GJ, Vallis Y, Peter BJ, Olesen LE, Gallop JL, Butler PJ, Evans PR, McMahon HT (2003). "EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking". J. Cell Biol. 160 (2): 213–22. doi:10.1083/jcb.200208023. PMC 2172650. PMID 12538641.
• Lui WW, Collins BM, Hirst J, Motley A, Millar C, Schu P, Owen DJ, Robinson MS (2003). "Binding partners for the COOH-terminal appendage domains of the GGAs and gamma-adaptin". Mol. Biol. Cell. 14 (6): 2385–98. doi:10.1091/mbc.E02-11-0735. PMC 194887. PMID 12808037.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Hirst J, Borner GH, Harbour M, Robinson MS (2005). "The aftiphilin/p200/gamma-synergin complex". Mol. Biol. Cell. 16 (5): 2554–65. doi:10.1091/mbc.E04-12-1077. PMC 1087257. PMID 15758025.
• Theos AC, Tenza D, Martina JA, Hurbain I, Peden AA, Sviderskaya EV, Stewart A, Robinson MS, Bennett DC, Cutler DF, Bonifacino JS, Marks MS, Raposo G (2005). "Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes". Mol. Biol. Cell. 16 (11): 5356–72. doi:10.1091/mbc.E05-07-0626. PMC 1266432. PMID 16162817.