In August 2020, Chandler was cast in a reboot of the 1998 slasher film Urban Legend set to be written and directed by Colin Minihan.[4] However, in October 2022, Minihan revealed that the film had been cancelled due to "bad timing".[5] Chandler ended up making her film debut with a supporting role in Olivia Wilde's psychological thriller Don't Worry Darling (2022).[6]
In January 2021, she was cast in the FX miniseries Pistol, a series about the Sex Pistols. Chandler played Chrissie Hynde, a founding member of the Pretenders.[7] She learned how to sing and play guitar to prepare for the role.[8] That same year, it was announced that Chandler would star in Susannah Grant's sex trafficking drama series Coercion for Showtime.[9] As of August 2024, production for the series has yet to start. Chandler has since appeared in the Apple TV+ mystery drama series Sugar (2024), alongside Colin Farrell.[10]
In May 2023, she was cast in the lead role of Noah Hawley's Alien: Earth for FX on Hulu.[11] Filming for the series wrapped in July 2024,[12] and is set to be released in 2025.