"Something Against You" is the seventh episode of the twelfth season of the American television medical dramaGrey's Anatomy, and the 252nd episode overall. Written by Andy Reaser and directed by Geary McLeod, the episode aired on the American Broadcasting Company (ABC) in the United States on November 12, 2015.
Upon its initial airing, "Something Against You" drew an audience of 8.02 million viewers, ranked #7 in viewership, and earned a 2.2/7 rating in the 18–49 demographic. It received mixed reviews from television critics, with praise for the performances of Pompeo, McKidd and James Pickens Jr. (Richard Webber).
Plot
The episode opens with a voice-over narration from Meredith Grey (Ellen Pompeo), emphasizing that vulnerability is not a weakness but an essential part of strength and growth.
Meredith takes Richard Webber’s (James Pickens Jr.) advice about working with Penelope "Penny" Blake (Samantha Sloyan), but she begins going too easy on Penny when a longtime elderly patient arrives for a kidney transplant. During the patient's evaluation, a large osteosarcoma is discovered on his skull, which puts the transplant on hold. However, Jo Wilson (Camilla Luddington) realizes that the kidney donor can also donate part of his skull, effectively removing the cancerous tumor and solving both issues.
Callie Torres (Sara Ramirez) attempts to confront Meredith about neglecting her responsibility to properly teach Penny, but Penny steps up for herself, asking Callie to let her fight her own battles. She also insists that Meredith be tough on her, so she can learn and grow as a surgeon.
"Something Against You" was originally broadcast on November 12, 2015, in the United States on the American Broadcasting Company (ABC). Upon its initial release, the episode was watched by a total of 8.02 million viewers and scored a 2.2/7 in the key 18–49 demographic in the Nielsen ratings, reflecting a decrease from the previous episode, "The Me Nobody Knows", which was viewed by 8.50 million viewers and received a 2.3/8 ratings/share.