Much of Jayachandran's work is in development economics, including maternal and child health in Africa and South Asia.[11] A substantial body of her research concerns gender differences.[1] In India, she finds that there is a tension between the desire for smaller families and the desire to have at least one son, making son preference stronger as family sizes shrink.[12] She estimates that fertility decline can explain one-third to one-half of the increase in the number of "missing women" in India.[13] In work with Erica Field and Rohini Pande, she also finds evidence that patriarchic gender norms in India constrain female entrepreneurship, with Muslim women (the sociocultural group with the most restrictions) being unable to benefit from business training.[14]
Another important focus of Jayachandran's research revolves around deforestation in Indonesia and Uganda. In a 2008 publication, she showed that massive forest fires in Indonesia caused air pollution that had adverse impacts on pregnant women and babies in poor communities, leading to more than 15,000 fetal and infant deaths.[15] In 2017, with a group of collaborators, she published research in Science showing that landowners in Uganda would preserve forests if they were paid to preserve forest cover.[1] She found that landowners who were offered a conservation contract only cleared 4% of land as opposed to the 9% cleared in villages without a contract.[16] This delayed 3000 metric tons of carbon dioxide at a cost of 46 cents per ton.[16] These results were covered in the New York Times.[17]
However, her most cited article[18] is about the impact that the departure of US Senator Jim Jeffords from the Republican to the Democratic Parties in 2001 had on the valuation of companies that had previously donated large sums of money to Republican Senators.[19] This was the first economics paper she wrote.[20]
Jayachandran, Seema. "Selling labor low: Wage responses to productivity shocks in developing countries." Journal of political Economy 114, no. 3 (2006): 538-575.
Jayachandran, Seema, and Adriana Lleras-Muney. "Life expectancy and human capital investments: Evidence from maternal mortality declines." The Quarterly Journal of Economics 124, no. 1 (2009): 349-397.
Jayachandran, Seema, and Ilyana Kuziemko. "Why do mothers breastfeed girls less than boys? Evidence and implications for child health in India." The Quarterly journal of economics 126, no. 3 (2011): 1485-1538.
Field, Erica; Jayachandran, Seema; Pande, Rohini (May 1, 2010). "Do Traditional Institutions Constrain Female Entrepreneurship? A Field Experiment on Business Training in India". American Economic Review. 100 (2). American Economic Association: 125–129. doi:10.1257/aer.100.2.125. ISSN0002-8282.
Jayachandran, Seema, and Michael Kremer. "Odious debt." American Economic Review 96, no. 1 (2006): 82-92.