Nance grew up in Austin, Texas.[6] She became interested in the solar system as a child, and used to listen to StarDate on the radio on her way home from school.[12] She has said that her St. Stephen's Episcopal School's high school physics teacher, Frank Mikan, encouraged her love of space science.[12]
In 2017, Nance moved to the University of California, Berkeley for her graduate studies, where she investigates supernovae and uses them as a means to study both the make-up and ultimate fate of the universe. Here she earned an Master of Science (MS) degree in astronomy, before beginning a doctoral programme.[12] In particular, Nance studies the evolutionary state of Betelgeuse.[16] She works with the Lawrence Berkeley National Laboratory Centre for Computational Cosmology to use supercomputers to build models of the explosions of supernovae in their final stages.[17][18][19]
During the first year of her undergraduate degree Nance worked as an intern at the McDonald Observatory.[12] After starting her doctoral degree, Nance took to her science communication online.[16] One of her viral tweets on Twitter, which highlighted how important failure was in science, was picked up by Sundar Pichai.[20]
Nance is an activist for women's health. In her early 20s it was identified that she had inherited the BRCA2 gene from her father, which is known to be a predictor of breast cancer.[21] Nance used a crowdfunding campaign to raise money to cover the cost of a double mastectomy, and her social media platform to advocate for early and frequent testing as well as preventive medicine.[22][23][24] After searching for the best local surgeons, Nance identified Anne Peled, a Californian reconstructive surgeon who was also a survivor of breast cancer.[21] Nance underwent the surgery in 2019.[21]
On January 15, 2021, Seeker released the internet television astronomy series Constellations, hosted by Nance.[7][25]
Nance's memoir Starstruck was published in 2023.[10] which explains various aspects of astronomy alongside telling her experiences growing up and entering a career in astronomy.[2]