Saguaro's varsity football program has won an Arizona state championship fourteen times (1995, 2006, 2007, 2008, 2010, 2011, 2013, 2014, 2015, 2016, 2017, 2018, 2021, and 2023).
The varsity baseball program is four time state champions (1992, 2010, 2011 and 2024).
The varsity boys' basketball program has won three state championships (1990, 1996, and 2004). The varsity girls' basketball program won one state title, in 2013.
The SHS varsity golf programs have combined for four state titles (boys' golf in 1977 and 1990; girls' golf in 1997 and 1998).
The girls' swim and dive team won one state title, in 1971.
Saguaro Track and Field has had several athletes win state: in the 4x440yrd relay in 1978, in the 300m hurdles in 1995, in the 3200m run in 2016 and 2017, and the 100m, 200m and 4x100m relay in 2018 and 2019 respectively.
The men's tennis teams through 2009-2013 reached the state playoffs four years in a row led by the 2013 senior class.
The Saguaro senior class of 1996 won the school's first ever football state championship, and also won the basketball state championship. The baseball team lost in the state championship final, finishing 2nd in the state.