Rudolf Buchheim

Rudolf Buchheim
Born1 March 1820 Edit this on Wikidata
Bautzen Edit this on Wikidata
Died25 December 1879 Edit this on Wikidata (aged 59)
Giessen Edit this on Wikidata
Alma mater
OccupationPharmacologist, physician, pharmacist Edit this on Wikidata
Employer

Rudolf Buchheim (1 March 1820 – 25 December 1879) was a German pharmacologist born in Bautzen (Budziszyn).[1]

Rudolf Bucheim and his well-known student, chemist Oswald Schmiedeberg (1838–1921) are considered to be the founders of modern pharmacology, with Bucheim sometimes described as the "Father of Pharmacology".[2][3][4]

Career

On January 7, 1845 Buchheim received his doctorate from the University of Leipzig and on 28th of February in 1847 he accepted a position an associate professor of pharmacology, dietetics, history of medicine and medical literature at the University of Dorpat. He converted part of his own home into the first pharmacological laboratory, financing the research himself and training his students there. In 1849 he was chosen as a full professor of pharmacology. By 1856 he had established the first pharmacological institute at Dorpat, moving into the laboratory space even before it was finished. In 1866 Buchheim received an offer of a professorship from the University of Giessen, where he remained until his death.[1]

Research

Buchheim is remembered for his pioneer work in experimental pharmacology. He was instrumental in turning pharmacology from an empirical study of medicine into an independent medical discipline.[5] Buchheim introduced two principles which helped to establish a scientific foundation for therapeutics, which he saw as "a new era of pharmacology".[1] First was the classification of drugs into a natural system" based on mode of action, through scientific experiment, statistical analysis. and the understanding of drug effects.[1] Second, through the founding pharmacological laboratories and training of others, he systematically explored experimental pharmacological and created a methodology for determining the quantitative and medical aspects of chemical substances.[6] In this way he established pharmacology as an independent science with its own philosophy and methods.[2]

"If we translate our often obscure ideas about drug actions into an exact physiological language: this should, without doubt, be a considerable achievement. However, scientific cognition of the action of a given drug would imply our ability to deduce each of its actions from its chemical formula." Buchheim[1]

While at Leipzig, Buchheim translated Jonathan Pereira's (1804–1853) textbook The Elements of Materia Medica from English into German. Buchheim also edited the book, eliminating obsolete and ineffectual medicines and practices, while adding updated information, including a chapter of his own called Art der Wirkung ("The Mode of Action").[6][7] He was also the author of a well-received textbook on pharmacology, titled Lehrbuch der Arzneimittellehre (1856).[1][8]

The Rudolf Buchheim Institute for Pharmacology is located at the University of Giessen.[9]

References

  1. ^ a b c d e f Habermann, Ernst R. (April 1974). "Rudolf Buchheim and the Beginning of Pharmacology as a Science". Annual Review of Pharmacology. 14 (1): 1–9. doi:10.1146/annurev.pa.14.040174.000245. ISSN 0066-4251. Retrieved 15 March 2023.
  2. ^ a b Reverte, Marı́a; Baños, Joseph-E. (1 March 2002). "Don't forget Buchheim". Trends in Pharmacological Sciences. 23 (3): 112. doi:10.1016/S0165-6147(02)02005-9. ISSN 0165-6147. PMID 11879676.
  3. ^ Scheindlin, Stanley (May 2001). "A brief history of pharmacology". Modern Drug Discovery. 4 (5): 87–88, 91.
  4. ^ Schmidt, Carl F. (March 1961). "Pharmacology in a Changing World". Annual Review of Physiology. 23 (1): 1–15. doi:10.1146/annurev.ph.23.030161.000245. ISSN 0066-4278. PMID 13747964. Retrieved 15 March 2023.
  5. ^ Bickel, M. H. (2000). "[The development of experimental pharmacology 1790-1850]". Gesnerus. Supplement. 46: 7–158. ISSN 1017-3293. PMID 11021040.
  6. ^ a b Scheindlin, Stanley (1 December 2010). "Our Man in Dorpat: Rudolf Buchheim and the Birth of Pharmacology". Molecular Interventions. 10 (6): 331–335. doi:10.1124/mi.10.6.1. ISSN 1534-0384. PMID 21263158. Retrieved 15 March 2023.
  7. ^ Schmiedeberg, O. (1912). "Rudolf Buchheim , sein Leben und seine Bedeutung für die Begründung der wissenschaftlichen Arzneimittellehre und Pharmakologie" (PDF). Arch. Exp. Pathol. Pharmakol. 67: 1–54. doi:10.1007/BF02012802. S2CID 13177711.
  8. ^ Leake, C D (April 1962). "Reviews of Reviews". Annual Review of Pharmacology. 2 (1): 415–430. doi:10.1146/annurev.pa.02.040162.002215. ISSN 0066-4251.
  9. ^ "Rudolf-Buchheim-Institut für Pharmakologie". Justus-Liebig-Universität Gießen (in German). Retrieved 15 March 2023.