Ribulose 5-phosphate

Ribulose 5-phosphate
Names
IUPAC name
  • D-Ribulose 5-phosphate
  • 5-O-Phosphono-D-ribulose
Systematic IUPAC name
[(2R,3R)-2,3,5-Trihydroxy-4-oxopentyl] dihydrogen phosphate
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
MeSH ribulose+5-phosphate
UNII
  • InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 checkY
    Key: FNZLKVNUWIIPSJ-UHNVWZDZSA-L checkY
  • InChI=1/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1
    Key: FNZLKVNUWIIPSJ-DAZPBWGKBO
  • C([C@H]([C@H](C(=O)CO)O)O)OP(=O)(O)O
Properties
C5H11O8P
Molar mass 230.109 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Ribulose 5-phosphate is one of the end-products of the pentose phosphate pathway. It is also an intermediate in the Calvin cycle.

It is formed by phosphogluconate dehydrogenase in the pentose phosphate pathway.[1][2] Ribulose 5-phosphate is involved in various metabolic pathways. Ribulose 5-phosphate can be acted upon by phosphopentose isomerase to form ribose 5-phosphate, which is a precursor for nucleotide and co-factor biosynthesis.[1] Ribulose-5 phosphate can also be acted upon by phosphopentose epimerase to form xylulose 5-phosphate, which is used in the nonoxidative phase of the pentose phosphate pathway in humans to generate precursor molecules for the synthesis of aromatic amino acids and production of energy.[2]

In plants, ribulose 5-phosphate produced from the pentose-phosphate pathway is converted into ribulose-1,5-bisphosphate by the enzyme phosphoribokinase.

See also

References

  1. ^ a b Edwards, Thomas E.; Abramov, Ariel B.; Smith, Eric R.; Baydo, Ruth O.; Leonard, Jess T.; Leibly, David J.; Thompkins, Kaitlin B.; Clifton, Matthew C.; Gardberg, Anna S.; Staker, Bart L.; Van Voorhis, Wesley C.; Myler, Peter J.; Stewart, Lance J. (2011-10-13). "Structural characterization of a ribose-5-phosphate isomerase B from the pathogenic fungus Coccidioides immitis". BMC Structural Biology. 11: 39. doi:10.1186/1472-6807-11-39. ISSN 1472-6807. PMC 3212906. PMID 21995815.
  2. ^ a b Liang, Wenguang; Ouyang, Songying; Shaw, Neil; Joachimiak, Andrzej; Zhang, Rongguang; Liu, Zhi-Jie (2010-10-05). "Conversion of<scp>d</scp>-ribulose 5-phosphate to<scp>D</scp>-xylulose 5-phosphate: new insights from structural and biochemical studies on human RPE". The FASEB Journal. 25 (2): 497–504. doi:10.1096/fj.10-171207. ISSN 0892-6638. PMC 6188353. PMID 20923965.