RRNA N-glycosylase

rRNA N-glycosylase
Ricin A chain, Ricinus communis
Identifiers
EC no.	3.2.2.22
CAS no.	113756-12-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

rRNA N-glycosylase (EC 3.2.2.22, ribosomal ribonucleate N-glycosidase, nigrin b, RNA N-glycosidase, rRNA N-glycosidase, ricin, momorcochin-S, Mirabilis antiviral protein, gelonin, saporins) is an enzyme with systematic name rRNA N-glycohydrolase.[1] This enzyme catalyses the following chemical reaction

Hydrolysis of the N-glycosylic bond at A-4324 in 28S rRNA from eukaryotic ribosomes.

Ricin A-chain and related toxins show this activity. The only protein family known to have this activity is the ribosome-inactivating protein (RIP) family.

References

1. Endo Y, Tsurugi K (June 1988). "The RNA N-glycosidase activity of ricin A-chain. The characteristics of the enzymatic activity of ricin A-chain with ribosomes and with rRNA". The Journal of Biological Chemistry. 263 (18): 8735–9. PMID 3288622.

External links

• RRNA+N-glycosylase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)