RCOR1
Protein-coding gene in the species Homo sapiens
RCOR1 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IW5 , 2UXN , 2UXX , 2V1D , 2X0L , 2XAF , 2XAG , 2XAH , 2XAJ , 2XAQ , 2XAS , 2Y48 , 3ZMS , 3ZMT , 3ZMU , 3ZMV , 3ZMZ , 3ZN0 , 3ZN1 , 4BAY , 4KUM , 4UV8 , 4UV9 , 4UVA , 4UVB , 4UVC , 4UXN , 5L3D , 5L3B , 5L3C , 4XBF
Identifiers Aliases RCOR1 , COREST, RCOR, REST corepressor 1External IDs OMIM : 607675 ; MGI : 106340 ; HomoloGene : 32246 ; GeneCards : RCOR1 ; OMA :RCOR1 - orthologs Wikidata
REST corepressor 1 also known as CoREST is a protein that in humans is encoded by the RCOR1 gene .[ 5] [ 6]
Function
This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation . The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor).[ 6]
Interactions
RCOR1 has been shown to interact with
References
^ a b c GRCh38: Ensembl release 89: ENSG00000089902 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037896 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ a b Andrés ME, Burger C, Peral-Rubio MJ, Battaglioli E, Anderson ME, Grimes J, Dallman J, Ballas N, Mandel G (September 1999). "CoREST: a functional corepressor required for regulation of neural-specific gene expression" . Proc. Natl. Acad. Sci. U.S.A . 96 (17): 9873–8. Bibcode :1999PNAS...96.9873A . doi :10.1073/pnas.96.17.9873 . PMC 22303 . PMID 10449787 .
^ a b "Entrez Gene: RCOR1 REST corepressor 1" .
^ a b c d Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R (May 2002). "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes" . Proc. Natl. Acad. Sci. U.S.A . 99 (11): 7420–5. Bibcode :2002PNAS...99.7420H . doi :10.1073/pnas.112008599 . PMC 124246 . PMID 12032298 .
^ a b You A, Tong JK, Grozinger CM, Schreiber SL (February 2001). "CoREST is an integral component of the CoREST- human histone deacetylase complex" . Proc. Natl. Acad. Sci. U.S.A . 98 (4): 1454–8. Bibcode :2001PNAS...98.1454Y . doi :10.1073/pnas.98.4.1454 . PMC 29278 . PMID 11171972 .
^ Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T (September 2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression". Biochem. Biophys. Res. Commun . 322 (2): 601–8. doi :10.1016/j.bbrc.2004.07.163 . PMID 15325272 .
Further reading
Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (1994). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1" . DNA Res . 1 (5): 223–9. doi :10.1093/dnares/1.5.223 . PMID 7584044 .
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem . 236 (1): 107–13. doi :10.1006/abio.1996.0138 . PMID 8619474 .
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing" . Genome Res . 7 (4): 353–8. doi :10.1101/gr.7.4.353 . PMC 139146 . PMID 9110174 .
Grimes JA, Nielsen SJ, Battaglioli E, Miska EA, Speh JC, Berry DL, Atouf F, Holdener BC, Mandel G, Kouzarides T (2000). "The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex" . J. Biol. Chem . 275 (13): 9461–7. doi :10.1074/jbc.275.13.9461 . PMID 10734093 .
Hartley JL, Temple GF, Brasch MA (2000). "DNA cloning using in vitro site-specific recombination" . Genome Res . 10 (11): 1788–95. doi :10.1101/gr.143000 . PMC 310948 . PMID 11076863 .
Humphrey GW, Wang Y, Russanova VR, Hirai T, Qin J, Nakatani Y, Howard BH (2001). "Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1" . J. Biol. Chem . 276 (9): 6817–24. doi :10.1074/jbc.M007372200 . PMID 11102443 .
You A, Tong JK, Grozinger CM, Schreiber SL (2001). "CoREST is an integral component of the CoREST- human histone deacetylase complex" . Proc. Natl. Acad. Sci. U.S.A . 98 (4): 1454–8. Bibcode :2001PNAS...98.1454Y . doi :10.1073/pnas.98.4.1454 . PMC 29278 . PMID 11171972 .
Ballas N, Battaglioli E, Atouf F, Andres ME, Chenoweth J, Anderson ME, Burger C, Moniwa M, Davie JR, Bowers WJ, Federoff HJ, Rose DW, Rosenfeld MG, Brehm P, Mandel G (2001). "Regulation of neuronal traits by a novel transcriptional complex" . Neuron . 31 (3): 353–65. doi :10.1016/S0896-6273(01)00371-3 . PMID 11516394 .
Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R (2002). "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes" . Proc. Natl. Acad. Sci. U.S.A . 99 (11): 7420–5. Bibcode :2002PNAS...99.7420H . doi :10.1073/pnas.112008599 . PMC 124246 . PMID 12032298 .
Battaglioli E, Andrés ME, Rose DW, Chenoweth JG, Rosenfeld MG, Anderson ME, Mandel G (2002). "REST repression of neuronal genes requires components of the hSWI.SNF complex" . J. Biol. Chem . 277 (43): 41038–45. doi :10.1074/jbc.M205691200 . PMID 12192000 .
Lunyak VV, Burgess R, Prefontaine GG, Nelson C, Sze SH, Chenoweth J, Schwartz P, Pevzner PA, Glass C, Mandel G, Rosenfeld MG (2002). "Corepressor-dependent silencing of chromosomal regions encoding neuronal genes". Science . 298 (5599): 1747–52. Bibcode :2002Sci...298.1747L . CiteSeerX 10.1.1.136.7131 . doi :10.1126/science.1076469 . PMID 12399542 . S2CID 13507921 .
Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R (2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes" . J. Biol. Chem . 278 (9): 7234–9. doi :10.1074/jbc.M208992200 . PMID 12493763 .
Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T (2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression". Biochem. Biophys. Res. Commun . 322 (2): 601–8. doi :10.1016/j.bbrc.2004.07.163 . PMID 15325272 .
Gu H, Liang Y, Mandel G, Roizman B (2005). "Components of the REST/CoREST/histone deacetylase repressor complex are disrupted, modified, and translocated in HSV-1-infected cells" . Proc. Natl. Acad. Sci. U.S.A . 102 (21): 7571–6. Bibcode :2005PNAS..102.7571G . doi :10.1073/pnas.0502658102 . PMC 1140450 . PMID 15897453 .
Lee MG, Wynder C, Cooch N, Shiekhattar R (2005). "An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation". Nature . 437 (7057): 432–5. Bibcode :2005Natur.437..432L . doi :10.1038/nature04021 . PMID 16079794 . S2CID 4396351 .
Shi YJ, Matson C, Lan F, Iwase S, Baba T, Shi Y (2005). "Regulation of LSD1 histone demethylase activity by its associated factors" . Mol. Cell . 19 (6): 857–64. doi :10.1016/j.molcel.2005.08.027 . PMID 16140033 .
Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (2006). "Phosphoproteome analysis of the human mitotic spindle" . Proc. Natl. Acad. Sci. U.S.A . 103 (14): 5391–6. Bibcode :2006PNAS..103.5391N . doi :10.1073/pnas.0507066103 . PMC 1459365 . PMID 16565220 .
PDB gallery
2iw5 : STRUCTURAL BASIS FOR COREST-DEPENDENT DEMETHYLATION OF NUCLEOSOMES BY THE HUMAN LSD1 HISTONE DEMETHYLASE
2uxn : STRUCTURAL BASIS OF HISTONE DEMETHYLATION BY LSD1 REVEALED BY SUICIDE INACTIVATION
2v1d : STRUCTURAL BASIS OF LSD1-COREST SELECTIVITY IN HISTONE H3 RECOGNITION
This article incorporates text from the United States National Library of Medicine , which is in the public domain .