The Primera División de Fútbol Profesional Apertura 2001 season (officially "Torneo Apertura 2001"), started on August 26, 2001, and finished on December 23, 2001.
This was the first season that saw promotion/relegation used on a once a year basis, rather than every six months as had been a custom in previous years. This meant that teams could now only be promoted/relegated once a year, after both the Apertura and Clausura seasons had ended. At which time, the teams promoted/relegated would be decided by comparing accumulated points on aggregate over both Apertura and Clausura seasons. At this point, the bottom team would automatically be relegated to the Segunda División de Fútbol Salvadoreño, while the winner of that division would be brought up to take their spot.