Prednicarbate

Prednicarbate
Clinical data
Other names{2-[(8S,9S,10R,11S,13S,14S,17R)-17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl} propanoate
AHFS/Drugs.comMonograph
MedlinePlusa604021
Routes of
administration		Topical
ATC code
Identifiers
  • 17-[(Ethoxycarbonyl)oxy]-11β-hydroxy-3,20-dioxopregna-1,4-dien-21-yl propionate
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.070.516 Edit this at Wikidata
Chemical and physical data
FormulaC27H36O8
Molar mass488.577 g·mol−1
3D model (JSmol)
  • O=C(OCC(=O)[C@@]1(OC(=O)OCC)CC[C@H]2[C@H]4[C@H]([C@@H](O)C[C@]12C)[C@]/3(/C=C\C(=O)\C=C\3CC4)C)CC
  • InChI=1S/C27H36O8/c1-5-22(31)34-15-21(30)27(35-24(32)33-6-2)12-10-19-18-8-7-16-13-17(28)9-11-25(16,3)23(18)20(29)14-26(19,27)4/h9,11,13,18-20,23,29H,5-8,10,12,14-15H2,1-4H3/t18-,19-,20-,23+,25-,26-,27-/m0/s1 ☒N
  • Key:FNPXMHRZILFCKX-KAJVQRHHSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Prednicarbate is a relatively new topical corticosteroid drug. It is similar in potency to hydrocortisone. Corticosteroids have always been an important part of the pharmacological arsenal of dermatology; however, their tendency to produce side-effects has caused the need to search for new preparations.[1]

It is nonhalogenated.[2]

References

  1. ^ United States Pharmacopeia, the National Formulary. United States Pharmacopeial Convention, Incorporated. 2008. p. 3060. ISBN 978-1-889788-53-1.
  2. ^ Gupta AK, Chow M (2004). "A review of prednicarbate (Dermatop)". Skin Therapy Lett. 9 (10): 5–6, 9. PMID 15657633.


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