Paul Schedl

Paul Schedl
Born (1947-11-07) November 7, 1947 (age 77)
Iowa City, Iowa
EducationStanford University (PhD 1975)
Known forControl of gene expression in developmental systems
Parents
  • Harold Schedl (father)
  • Naomi Schedl (mother)
RelativesAndrew Schedl, Timothy Schedl (brothers)
Scientific career
FieldsMolecular biology, genetics
InstitutionsUniversity of Basel, Switzerland (Helen Hay Whitney fellow); Princeton University
Academic advisorsWalter Gehring

Paul Daniel Schedl (born November 7, 1947, in Iowa City, Iowa) is a Professor of Molecular Biology at Princeton University.

Schedl has made significant contributions to the field of the control of gene expression in developmental systems using the model system Drosophila melanogaster. On the genomic level, his lab has uncovered the mechanisms of chromatin regulation by the Polycomb and trithorax group genes.[1] At the transcriptional and post-transcriptional level, he made discoveries in the regulation of alternative splicing of the sex determination gene, Sxl.[2][3][4] At the level of translational control, he discovered the function of the orb and orb2 gene in early development.[5]

Schedl obtained his PhD in 1975 at Stanford University, and was a Helen Hay Whitney postdoctoral fellow in Walter Gehring's lab at the University of Basel, Switzerland.[6] Schedl has been a member of the faculty at Princeton University since 1978.

As of 2006, Schedl has published 132 papers, mentored 28 graduate students, sponsored 25 postdoctoral fellows and collaborated with 79 scientists.

Schedl was born to Harold Schedl, a professor of chemistry at the University of Iowa, and Naomi Schedl, a professor of art. He has two brothers, Andrew Schedl and Timothy Schedl.

References

  1. ^ Chetverina, Darya; Erokhin, Maksim; Schedl, Paul (2021). "GAGA factor: a multifunctional pioneering chromatin protein". Cell. Mol. Life Sci. 78 (9): 4125–4141. doi:10.1007/s00018-021-03776-z. PMC 8815297. PMID 33528710.
  2. ^ Deshpande, Girish; Samuel, Mark E.; Schedl, Paul D. (1996). "Sex-lethal Interacts with Splicing Factors In Vitro and In Vivo". Molecular and Cellular Biology. 16 (9): 5036–5047. doi:10.1128/MCB.16.9.5036. PMC 231505. PMID 8756662.
  3. ^ Merritt, J.I. (September 30, 1987). "Fruit Flies". Princeton Alumni Weekly. Vol. 88. Princeton University Press. p. 19. Retrieved July 30, 2021.
  4. ^ Patrusky, Ben (Fall 1992). "The Intron Story". Mosaic. Vol. 23, no. 3. The Foundation. p. 33. Retrieved July 30, 2021.
  5. ^ Gilmutdinov, Rudolf; Kozlov, Eugene N.; Yakovlev, Konstantin V.; Olenina, Ludmila V.; Kotov 3, Alexei A.; Barr, Justinn; Zhukova, Mariya; Schedl, Paul; Shidlovskii, Yulii V. (2021). "The 3'UTR of the Drosophila CPEB translation factor gene orb2 plays a crucial role in spermatogenesis". Development. 148 (17): dev198788. doi:10.1242/dev.198788. PMC 8513165. PMID 34473243.{{cite journal}}: CS1 maint: numeric names: authors list (link)
  6. ^ Schedl, Paul; Artavanis-Tsakonas, Spyridon; Steward, Ruth; Gehring, Walter J.; Mirault, Marc-Edouard; Goldschmidt-Clermont, Michel; Moran, Larry; Tissières, Alfred (1978). "Two hybrid plasmids with D. melanogaster DNA sequences complementary to mRNA coding for the major heat shock protein". Cell. 14 (4): 921–929. doi:10.1016/0092-8674(78)90346-X. PMID 99246.