^The match, originally scheduled at 19:00 EDT (UTC−4), was delayed until 20:57 EDT due to thunderstorms in the area.[4][5][6]
^The match, originally scheduled at 21:30 EDT (UTC−4), was delayed until 23:30 EDT due to the weather delay in the Group C match between Costa Rica and Jamaica.[7]
^The Panama v Mexico match was originally scheduled on 8 September 2021, 20:05 local time,[8] but was rescheduled to 19:05 local time since Panama maintains a curfew which begins at 00:00 as a preventive measure against the COVID-19 pandemic.[9]
^The Panama v United States match was originally scheduled on 10 October 2021, 20:05 local time, but was rescheduled to 17:00 local time.[10]
^The El Salvador v Panama match was suspended at 3–2 in the 67th minute due to a thunderstorm in the vicinity of the stadium. The match was later cancelled and does not count for Panama's statistics.[11]