Oxantel

Oxantel
Clinical data
ATC code
Identifiers
  • 3-[(E)-2-(1-Methyl-5,6-dihydro-4H-pyrimidin-2-yl)ethenyl]phenol
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC13H16N2O
Molar mass216.284 g·mol−1
3D model (JSmol)
  • CN1CCCN=C1/C=C/C2=CC(=CC=C2)O
  • InChI=1S/C13H16N2O/c1-15-9-3-8-14-13(15)7-6-11-4-2-5-12(16)10-11/h2,4-7,10,16H,3,8-9H2,1H3/b7-6+ ☒N
  • Key:VRYKTHBAWRESFI-VOTSOKGWSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Oxantel is an anthelmintic. It has typically been used in human and animal medicine as a treatment for intestinal worms.[1] It has also been shown to inhibit fumarate reductase in some pathogenic bacteria.[2]

Similarly to pyrantel, oxantel depolarises the neurons of gastrointestinal parasites 100x more than acetylcholine, causing sustained muscular contraction, causing the parasites to die by spastic paralysis. This anthelmintic is commonly used to treat domestic animals as well as livestock, and resistance has been reported in both groups of animals.[3]

References

  1. ^ Palmeirim MS, Specht S, Scandale I, Gander-Meisterernst I, Chabicovsky M, Keiser J (June 2021). "Preclinical and Clinical Characteristics of the Trichuricidal Drug Oxantel Pamoate and Clinical Development Plans: A Review". Drugs. 81 (8): 907–921. doi:10.1007/s40265-021-01505-1. PMC 8144136. PMID 33929716.
  2. ^ Dashper S, O'Brien-Simpson N, Liu SW, Paolini R, Mitchell H, Walsh K, et al. (2014). "Oxantel disrupts polymicrobial biofilm development of periodontal pathogens". Antimicrobial Agents and Chemotherapy. 58 (1): 378–85. doi:10.1128/AAC.01375-13. PMC 3910723. PMID 24165189.
  3. ^ Kopp SR, Kotze AC, McCarthy JS, Traub RJ, Coleman GT (November 2008). "Pyrantel in small animal medicine: 30 years on". Veterinary Journal. 178 (2): 177–184. doi:10.1016/j.tvjl.2007.06.021. PMID 17720556.


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