Osvaldo Gutierrez

Osvaldo Gutierrez (born 1983) is an organic chemist, who uses computer models to analyze chemical reactions with the aim of making medicine more affordable.

Early life and education

Gutierrez was born in Rancho Los Prietos,[1][2] Salamanca in the state of Guanajuato.[2][3] He was nine years old when his family immigrated to the United States in 1993.[3] He was raised in Sacramento, California.[3]

Gutierrez attended Sacramento City College. In 2006, Gutierrez transferred to the University of California, Los Angeles (UCLA) where he obtained both his Bachelor's (B.S.) and Master's (M.S.) degrees in chemistry in 2009.[4][3][5] Out of 14 siblings, he was the first one to graduate from high school and college.[3][5]

In 2012, Gutierrez received legal status through the Deferred Action for Childhood Arrivals (DACA) program.[2] With the passing of the California Dream Act, Gutierrez earned his doctorate from University of California, Davis (UCD) in 2012,[3][5] and started a postdoctoral fellowship at the University of Pennsylvania from 2012 to 2016.[6][2]

Career and research

In 2016, after Gutierrez completed his postdoctoral fellowship at the University of Pennsylvania, he became an assistant professor at the University of Maryland, College Park in the chemistry and biochemistry department.[3][1] In 2021, Gutierrez was hired as an associate professor at Texas A&M University.[4]

Gutierrez uses computer modeling to help understand chemical reactions before trying traditional methods.[3] Gutierrez's model helps to experiment with less resources and predict how the atoms and molecules will arrange themselves during the chemical reactions, giving scientists a more accurate prediction.[7]

Iron(III)-sulfate-3D-balls-ionic

Gutierrez researched the use of iron (Fe) as a catalyst to a carbon to carbon bonds to produce safer and less expensive medicine, and researched how light impacts the process of making medicinal compounds.[7] Iron is not a good element to work with because it is very reactive and has too many radicals, complex electron interactions, and oxidation states.[2] With technology advancements, chemists were able to bypass that and catalyzed Fe cross couplings that enabled to unionize and diverse the carbon centered radicals.[8] Before this research, chemists were mostly using an element called palladium, which is easy to work with, very expensive, and toxic; whereas, iron is more complex, but less expensive, abundant and nontoxic.[9]

Gutierrez works with the Alliance for Diversity in Science and Engineering (ADSE) to support underrepresented people in STEM.[5][2]

Selected publications

  • Tapas Maity, Ángel Rentería-Gómez, and Osvaldo Gutierrez. "Stereoselective Fe-Catalyzed Decoupled Cross-Couplings: Chiral Vinyl Oxazolidinones as Effective Radical Lynchpins for Diastereoselective C(sp2)–C(sp3) Bond Formation." ACS Catalysis. 2024 14 (17), 13049-13054, DOI: 10.1021/acscatal.4c04568.
  • Macayla Guerrero, Ángel Rentería-Gómez, Deborshee Das and Osvaldo Gutierrez. "Expanding the chemical space of enol silyl ethers: catalytic dicarbofunctionalization enabled by iron catalysis." Chemical Science. 2023,14, 13007-13013, DOI: 10.1039/D3SC04549H.
  • Lei Liu, Maria Camila Aguilera, Wes Lee, Cassandra R. Youshaw, Michael L. Neidig, Osvaldo Gutierrez. "General method for iron-catalyzed multicomponent radical cascades–cross-couplings." Science 374, 432-439(2021), DOI:10.1126/science.abj6005
  • Lei Liu; Wes Lee; Cassandra R. Youshaw; Mingbin Yuan; Michael B. Geherty; Peter Y. Zavalij; Osvaldo Gutierrez. "Fe-catalyzed three-component dicarbofunctionalization of unactivated alkenes with alkyl halides and Grignard reagents." Chemical Science. 2020,11, 8301-8305, DOI: 10.1039/D0SC02127J.

Awards and recognition

Gutierrez was awarded the $1.9 million Maximizing Investigators’ Research Award (MIRA) from the National Institutes of Health (NIH) from 2020 to 2024.[3][7] Gutierrez was awarded the National Science Foundation CAREER Award in 2018, and again in 2022 for his "Computational and Experimental Mechanistic Approach to Iron Catalyst and Reaction Design" research.[10][11]

In 2020, Gutierrez was selected for American Chemistry Society's Chemical & Engineering News “Talented 12" recognition.[12][13] In 2019, Gutierrez was named the first Nathan Drake Faculty Fellow at the University of Maryland department of chemistry and biochemistry for his combination of computational chemistry and experimentation in organic chemistry research.[9]

References

  1. ^ a b Bliger-Coyne, Abbey (6 January 2021). "Career Conversations: Q&A with Organic Chemist Osvaldo Gutierrez". Biomedical Beat Blog. National Institute of General Medical Sciences. Retrieved 2024-10-20.
  2. ^ a b c d e f Lemonick, Sam (2020-08-14). "C&EN's Talented 12: Osvaldo Gutierrez". Chemical & Engineering News. American Chemical Society. Retrieved 2024-10-25.
  3. ^ a b c d e f g h i Farrell, Liam (Oct 12, 2020). "I Still Consider Myself Undocumented". Maryland Today. Retrieved 2024-10-17.
  4. ^ a b "Osvaldo Gutierrez - Texas A & M University". Dartmouth College Office of the President. 2022-11-10. Retrieved 2024-10-21.
  5. ^ a b c d "From undocumented child to professor: NorCal man shares his story". KCRA. 2019-02-04. Retrieved 2024-12-06.
  6. ^ "Osvaldo Gutierrez". Texas A&M University | Chemistry. Retrieved 2024-10-17.
  7. ^ a b c "UMD Chemistry and Biochemistry Osvaldo Gutierrez Receives $1.9M NIH MIRA Award". University of Maryland | Division of Research. 2020-07-28. Retrieved 2024-10-23.
  8. ^ Liu, Lei; Aguilera, Maria Camila; Lee, Wes; Youshaw, Cassandra R.; Neidig, Michael L.; Gutierrez, Osvaldo (21 October 2021). "General method for iron-catalyzed multicomponent radical cascades–cross-couplings". Science. 374 (6566): 432–439. Bibcode:2021Sci...374..432L. doi:10.1126/science.abj6005. PMC 8929405. PMID 34672739.
  9. ^ a b "Osvaldo Gutierrez Named First Nathan Drake Faculty Fellow". Department of Chemistry and Biochemistry | University of Maryland. Retrieved 2024-10-30.
  10. ^ "NSF Award Search: Award # 2221728 - CAREER: Computational and Experimental Mechanistic Approach to Iron Catalyst and Reaction Design". National Science Foundation. Retrieved 2024-10-30.
  11. ^ "NSF Award Search: Award # 1751568 - CAREER: Computational and Experimental Mechanistic Approach to Iron Catalyst and Reaction Design". National Science Foundation. Retrieved 2024-10-30.
  12. ^ "'Talented 12: Chemical & Engineering News announces its 2020 rising stars in chemistry'". American Chemical Society. Retrieved 2024-10-20.
  13. ^ "Alumni News". UCLA Chemistry & Biochemistry. 2020-08-20. Retrieved 2024-10-28.