Neurogenin-1

NEUROG1
Identifiers
Aliases	NEUROG1, AKA, Math4C, NEUROD3, bHLHa6, ngn1, neurogenin 1
External IDs	OMIM: 601726; MGI: 107754; HomoloGene: 4490; GeneCards: NEUROG1; OMA:NEUROG1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.1 Start 135,534,282 bp[1] End 135,535,964 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 B1|13 30.06 cM Start 56,398,291 bp[2] End 56,399,976 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone right ovary Top expressed in ventricular zone urethra female urethra male urethra rhombic lip hair trigeminal ganglion Jacobson's organ embryo pretectal area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein dimerization activity DNA-binding transcription factor activity chromatin binding protein binding protein homodimerization activity E-box binding sequence-specific double-stranded DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component perikaryon soma nucleus Biological process regulation of neuron differentiation neurogenesis cell differentiation cell fate commitment regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II positive regulation of DNA-binding transcription factor activity positive regulation of exit from mitosis transcription, DNA-templated nervous system development multicellular organism development positive regulation of neuron differentiation neuron differentiation positive regulation of transcription by RNA polymerase II thorax and anterior abdomen determination trigeminal nerve development vestibulocochlear nerve formation peristalsis auditory behavior genitalia morphogenesis inner ear morphogenesis regulation of muscle organ development genitalia development inner ear development neuromuscular process controlling balance mastication cochlea development cochlea morphogenesis craniofacial suture morphogenesis learned vocalization behavior negative regulation of relaxation of muscle negative regulation of saliva secretion hard palate morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4762 18014 Ensembl ENSG00000181965 ENSMUSG00000048904 UniProt Q92886 P70660 RefSeq (mRNA) NM_006161 NM_010896 RefSeq (protein) NP_006152 NP_035026 Location (UCSC) Chr 5: 135.53 – 135.54 Mb Chr 13: 56.4 – 56.4 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Neurogenin-1 is a protein that in humans is encoded by the NEUROG1 gene.[5][6]

Interactions

NEUROG1 has been shown to interact with CREB-binding protein[7] and decapentaplegic homolog 1.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000181965 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000048904 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tamimi RM, Steingrimsson E, Montgomery-Dyer K, Copeland NG, Jenkins NA, Tapscott SJ (Mar 1997). "NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and 5q23-q31 and mouse chromosomes 11 and 13, respectively". Genomics. 40 (2): 355–7. doi:10.1006/geno.1996.4578. PMID 9119405.
6. "Entrez Gene: NEUROG1 neurogenin 1".
7. Sun Y, Nadal-Vicens M, Misono S, Lin MZ, Zubiaga A, Hua X, Fan G, Greenberg ME (Feb 2001). "Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms". Cell. 104 (3): 365–76. doi:10.1016/S0092-8674(01)00224-0. PMID 11239394. S2CID 1534352.

Further reading

• McCormick MB, Tamimi RM, Snider L, Asakura A, Bergstrom D, Tapscott SJ (Oct 1996). "NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family". Molecular and Cellular Biology. 16 (10): 5792–800. doi:10.1128/mcb.16.10.5792. PMC 231580. PMID 8816493.
• Sun Y, Nadal-Vicens M, Misono S, Lin MZ, Zubiaga A, Hua X, Fan G, Greenberg ME (Feb 2001). "Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms". Cell. 104 (3): 365–76. doi:10.1016/S0092-8674(01)00224-0. PMID 11239394. S2CID 1534352.
• Franklin A, Kao A, Tapscott S, Unis A (Nov 2001). "NeuroD homologue expression during cortical development in the human brain". Journal of Child Neurology. 16 (11): 849–53. doi:10.1177/08830738010160111201. PMID 11732772. S2CID 20069074.
• Kim S, Ghil SH, Kim SS, Myeong HH, Lee YD, Suh-Kim H (Dec 2002). "Overexpression of neurogenin1 induces neurite outgrowth in F11 neuroblastoma cells". Experimental & Molecular Medicine. 34 (6): 469–75. doi:10.1038/emm.2002.65. PMID 12526089.
• Fanous AH, Chen X, Wang X, Amdur RL, O'Neill FA, Walsh D, Kendler KS (Mar 2007). "Association between the 5q31.1 gene neurogenin1 and schizophrenia". American Journal of Medical Genetics Part B. 144B (2): 207–14. doi:10.1002/ajmg.b.30423. PMID 17044100. S2CID 24638656.
• Liscovitch N, Chechik G (2013). "Specialization of gene expression during mouse brain development". PLOS Computational Biology. 9 (9): e1003185. Bibcode:2013PLSCB...9E3185L. doi:10.1371/journal.pcbi.1003185. PMC 3777910. PMID 24068900.