On 10 July 2019, Pérez joined the newly promoted Primeira Liga side Famalicão on a season-long loan.[8][9] His opening appearance for them came in the Taça da Liga versus Covilhã on 3 August.[4] He scored his first senior goal on 31 August, netting in a league victory away from home against Aves.[10][11][12] He was named as the league's best defender for August.[13] In total, Pérez appeared twenty-five times during his time with Famalicão as they placed sixth.[4] He returned to his parent club ahead of the 2020–21 season, subsequently going unused on the bench for all three of Atlético's opening La Liga fixtures.[4]
On 5 October 2020, Pérez was loaned to fellow La Liga side Granada.[14] He made his debut on 25 October away to Getafe, which preceded his first UEFA Europa League appearances arriving on 5 November in Cyprus against Omonia.[4]
On 28 August 2021, Pérez joined Italian side Udinese on a season-long loan.[15] On 29 July 2022, he transferred to Udinese,[16] signing a five-year contract.[17]
On 30 August 2024, Pérez moved on loan to Porto, with an option to buy.[18]
^"Nehuén Pérez é Dragão" [Nehuén Pérez is a Dragon] (in ot). Porto. 30 August 2024. Retrieved 31 August 2024.{{cite web}}: CS1 maint: unrecognized language (link)