Nanoelectromechanical systems mass spectrometer

A nanoelectromechanical systems mass spectrometer (NEMS-MS) is an instrument measuring the mass of analyte particles by detecting the frequency shift caused by the adsorption of the particles on a NEMS resonator.

NEMS-MS was invented by Prof. Michael Roukes and Dr. Kamil Ekinci at the California Institute of Technology in 1999.[1][2] First attainment of attogram-scale mass sensitivity was documented in their 2001 patent disclosure. Successive NEMS-MS sensitivity milestones were reported by the Caltech researchers in publications appearing in 2004 (attogram-scale sensitivity)[3] and in 2006 (zeptogram-scale sensitivity).[4] They later developed single molecule analysis in 2009.[5][6] Single-biomolecule mass measurements were first accomplished by this team in 2012.[7] A hybrid NEMS-MS/TOF-MS instrument was reported in 2015.[8]

See also

References

  1. ^ US disclosure 2009/0261241, Roukes and Kamil Ekinci, "Apparatus and method for ultra sensitive nano electromechanical mass detection", published 2001-05-04 
  2. ^ US issued 6,722,200 B2, Roukes and Kamil Ekinci, "Apparatus and method for ultra sensitive nano electromechanical mass detection", published 2004-04-20 
  3. ^ Ekinci, K. L.; Huang, X. M. H.; Roukes, M. L. (2004). "Ultrasensitive nanoelectromechanical mass detection". Applied Physics Letters. 84 (22): 4469. arXiv:cond-mat/0402528. Bibcode:2004ApPhL..84.4469E. doi:10.1063/1.1755417. S2CID 118850381.
  4. ^ Yang, Y. T.; Callegari, C.; Feng, X. L.; Ekinci, K. L.; Roukes, M. L. (2006). "Zeptogram-Scale Nanomechanical Mass Sensing". Nano Letters. 6 (4): 583–6. Bibcode:2006NanoL...6..583Y. CiteSeerX 10.1.1.423.3616. doi:10.1021/nl052134m. PMID 16608248.
  5. ^ Naik, A. K.; Hanay, M. S.; Hiebert, W. K.; Feng, X. L.; Roukes, M. L. (21 June 2009). "Towards single-molecule nanomechanical mass spectrometry". Nature Nanotechnology. 4 (7): 445–450. Bibcode:2009NatNa...4..445N. doi:10.1038/nnano.2009.152. PMC 3846395. PMID 19581898.
  6. ^ US application 2009/0261241, Roukes et al, "Single molecule mass spectroscopy enabled by nanoelectromechanical systems (nems-ms)", published 2009-10-22 
  7. ^ Hanay, M. S.; Kelber, S. K.; Naik, A. K.; Chi, D.; Hentz, S.; Bullard, E.C.; Colinet, E.; Duraffourg, L.; Roukes, M.L. (26 August 2012). "Single-protein nanomechanical mass spectrometry in real time". Nature Nanotechnology. 7 (9): 602–608. Bibcode:2012NatNa...7..602H. doi:10.1038/NNANO.2012.119. PMC 3435450. PMID 22922541.
  8. ^ Sage, Eric; Brenac, Ariel; Alava, Thomas; Morel, Robert; Dupré, Cécilia; Hanay, Mehmet Selim; Roukes, Michael L.; Duraffourg, Laurent; Masselon, Christophe; Hentz, Sébastien (10 March 2015). "Neutral particle mass spectrometry with nanomechanical systems". Nature Communications. 6: 6482. arXiv:1405.7281. Bibcode:2015NatCo...6.6482S. doi:10.1038/ncomms7482. PMC 4366497. PMID 25753929.