NRXN2

NRXN2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4NXR
Identifiers
Aliases	NRXN2, neurexin 2
External IDs	OMIM: 600566; MGI: 1096362; HomoloGene: 86984; GeneCards: NRXN2; OMA:NRXN2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 64,606,174 bp[1] End 64,723,197 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 A|19 Start 6,468,761 bp[2] End 6,594,199 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum prefrontal cortex right frontal lobe Amygdala cingulate gyrus anterior cingulate cortex Brodmann area 9 ganglionic eminence paraflocculus of cerebellum cerebellar vermis Top expressed in Cerebellum cerebellar cortex olfactory bulb primary visual cortex superior frontal gyrus Hypothalamus striatum of neuraxis dentate gyrus of hippocampal formation granule cell hippocampus proper layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function neuroligin family protein binding transmembrane signaling receptor activity cell adhesion molecule binding calcium channel regulator activity metal ion binding Cellular component integral component of membrane membrane plasma membrane presynapse protein-containing complex Biological process neuron cell-cell adhesion cell adhesion signal transduction gephyrin clustering involved in postsynaptic density assembly postsynaptic density protein 95 clustering vocalization behavior vocal learning neuroligin clustering involved in postsynaptic membrane assembly adult behavior postsynaptic membrane assembly social behavior synapse assembly neurotransmitter secretion chemical synaptic transmission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9379 18190 Ensembl ENSG00000110076 ENSMUSG00000033768 UniProt P58401 Q9P2S2 E9Q7X7 RefSeq (mRNA) NM_015080 NM_138732 NM_138734 NM_001376262 NM_001376263 NM_001376265 NM_001376266 NM_001376267 NM_001400681 NM_001400682 NM_001205234 NM_001205235 NM_020253 NM_001369363 RefSeq (protein) NP_055895 NP_620060 NP_620063 NP_001363191 NP_001363192 NP_001363194 NP_001363195 NP_001363196 NP_055895.1 NP_620060.1 NP_001192163 NP_001192164 NP_064649 NP_001356292 Location (UCSC) Chr 11: 64.61 – 64.72 Mb Chr 19: 6.47 – 6.59 Mb PubMed search [3] [4]
Wikidata
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Neurexin-2-alpha is a protein that in humans is encoded by the NRXN2 gene.[5][6]

Neurexins are a family of proteins that function in the vertebrate nervous system as cell adhesion molecules and receptors. They are encoded by several unlinked genes of which two, NRXN1 and NRXN3, are among the largest known human genes. Three of the genes (NRXN1-3) utilize two alternate promoters and include numerous alternatively spliced exons to generate thousands of distinct mRNA transcripts and protein isoforms. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms; a much smaller number of transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000110076 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033768 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ushkaryov YA, Petrenko AG, Geppert M, Sudhof TC (Aug 1992). "Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin". Science. 257 (5066): 50–56. Bibcode:1992Sci...257...50U. doi:10.1126/science.1621094. PMID 1621094.
6. "Entrez Gene: NRXN2 neurexin 2".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Ichtchenko K, Nguyen T, Südhof TC (1996). "Structures, alternative splicing, and neurexin binding of multiple neuroligins". J. Biol. Chem. 271 (5): 2676–2682. doi:10.1074/jbc.271.5.2676. PMID 8576240.
• Hata Y, Butz S, Südhof TC (1996). "CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins". J. Neurosci. 16 (8): 2488–94. doi:10.1523/JNEUROSCI.16-08-02488.1996. PMC 6578772. PMID 8786425.
• Kurschner C, Mermelstein PG, Holden WT, Surmeier DJ (1998). "CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins". Mol. Cell. Neurosci. 11 (3): 161–172. doi:10.1006/mcne.1998.0679. PMID 9647694. S2CID 36534759.
• Hock B, Böhme B, Karn T, et al. (1998). "PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9779–9784. Bibcode:1998PNAS...95.9779H. doi:10.1073/pnas.95.17.9779. PMC 21413. PMID 9707552.
• Bergman L, Silins G, Grimmond S, et al. (1999). "A 500-kb sequence-ready cosmid contig and transcript map of the MEN1 region on 11q13". Genomics. 55 (1): 49–56. doi:10.1006/geno.1998.5625. PMID 9888998.
• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
• Rowen L, Young J, Birditt B, et al. (2002). "Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity". Genomics. 79 (4): 587–597. doi:10.1006/geno.2002.6734. PMID 11944992.
• Tabuchi K, Südhof TC (2002). "Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing". Genomics. 79 (6): 849–859. doi:10.1006/geno.2002.6780. PMID 12036300.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–1784. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Homma K, Kikuno RF, Nagase T, et al. (2004). "Alternative splice variants encoding unstable protein domains exist in the human brain". J. Mol. Biol. 343 (5): 1207–1220. doi:10.1016/j.jmb.2004.09.028. PMID 15491607.
• Taylor TD, Noguchi H, Totoki Y, et al. (2006). "Human chromosome 11 DNA sequence and analysis including novel gene identification". Nature. 440 (7083): 497–500. Bibcode:2006Natur.440..497T. doi:10.1038/nature04632. PMID 16554811.