NEMF (gene)

NEMF
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J92
Identifiers
Aliases	NEMF, NY-CO-1, SDCCAG1, nuclear export mediator factor, IDDSAPN
External IDs	OMIM: 608378; MGI: 1918305; HomoloGene: 3458; GeneCards: NEMF; OMA:NEMF - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q21.3 Start 49,782,083 bp[1] End 49,852,821 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 C2 Start 69,357,296 bp[2] End 69,403,939 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon internal globus pallidus sperm Brodmann area 23 pylorus corpus callosum external globus pallidus epithelium of colon sural nerve inferior ganglion of vagus nerve Top expressed in hand seminal vesicula mammillary body lobe of prostate ventromedial nucleus lateral geniculate nucleus fossa lateral hypothalamus pineal gland lateral septal nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function tRNA binding ribosomal large subunit binding Cellular component nucleus RQC complex Biological process nuclear export rescue of stalled ribosome ribosome-associated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9147 66244 Ensembl ENSG00000165525 ENSMUSG00000020982 UniProt O60524 Q8CCP0 RefSeq (mRNA) NM_001301732 NM_004713 NM_025441 NM_181665 RefSeq (protein) NP_001288661 NP_004704 NP_079717 Location (UCSC) Chr 14: 49.78 – 49.85 Mb Chr 12: 69.36 – 69.4 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Nuclear export mediator factor (NEMF) is a protein that in humans is encoded by the NEMF gene.[5]

Function

This gene encodes a component of the ribosome quality control complex.[6] The encoded protein facilitates the recognition and ubiquitination of stalled 60S subunits by the ubiquitin ligase listerin. A similar protein in fly functions as a tumor suppressor.

References

1. GRCh38: Ensembl release 89: ENSG00000165525 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020982 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Nuclear export mediator factor".
6. Shao S, Brown A, Santhanam B, Hegde RS (February 2015). "Structure and assembly pathway of the ribosome quality control complex". Molecular Cell. 57 (3): 433–44. doi:10.1016/j.molcel.2014.12.015. PMC 4321881. PMID 25578875.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.