NDST2

NDST2
Identifiers
Aliases	NDST2, HSST2, NST2, N-deacetylase/N-sulfotransferase 2, N-deacetylase and N-sulfotransferase 2, N-HSST 2
External IDs	OMIM: 603268; MGI: 97040; HomoloGene: 20803; GeneCards: NDST2; OMA:NDST2 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q22.2 Start 73,801,911 bp[1] End 73,811,798 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 A3 Start 20,773,798 bp[2] End 20,784,630 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen granulocyte blood bone marrow tonsil right hemisphere of cerebellum gastric mucosa minor salivary glands sural nerve appendix Top expressed in neural layer of retina granulocyte dermis lip ankle joint ventricular zone yolk sac tail of embryo spermatocyte decidua More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity sulfotransferase activity catalytic activity hydrolase activity N-acetylglucosamine deacetylase activity [heparan sulfate-glucosamine N-sulfotransferase activity] deacetylase activity heparan sulfate sulfotransferase activity heparan sulfate N-acetylglucosaminyltransferase activity Cellular component integral component of membrane Golgi membrane Golgi apparatus membrane Biological process metabolism heparan sulfate proteoglycan biosynthetic process heparin biosynthetic process glycosaminoglycan biosynthetic process regulation of angiotensin levels in blood cellular process or phenomenon sulfur compound metabolic process heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8509 17423 Ensembl ENSG00000166507 ENSMUSG00000039308 UniProt P52849 P52850 RefSeq (mRNA) NM_001330107 NM_003635 NM_010811 RefSeq (protein) NP_001317036 NP_003626 NP_034941 Location (UCSC) Chr 10: 73.8 – 73.81 Mb Chr 14: 20.77 – 20.78 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 is an enzyme that in humans is encoded by the NDST2 gene.[5][6]

References

1. GRCh38: Ensembl release 89: ENSG00000166507 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039308 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Humphries DE, Lanciotti J, Karlinsky JB (Jul 1998). "cDNA cloning, genomic organization and chromosomal localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase-2". Biochem J. 332 (2): 303–7. doi:10.1042/bj3320303. PMC 1219482. PMID 9601056.
6. "Entrez Gene: NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2".

Further reading

• Esko JD, Selleck SB (2002). "Order out of chaos: assembly of ligand binding sites in heparan sulfate". Annu. Rev. Biochem. 71: 435–71. doi:10.1146/annurev.biochem.71.110601.135458. PMID 12045103.
• Aikawa J, Esko JD (1999). "Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family". J. Biol. Chem. 274 (5): 2690–5. doi:10.1074/jbc.274.5.2690. PMID 9915799.
• Forsberg E, Pejler G, Ringvall M, et al. (1999). "Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme". Nature. 400 (6746): 773–6. Bibcode:1999Natur.400..773F. doi:10.1038/23488. PMID 10466727. S2CID 4428529.
• Pikas DS, Eriksson I, Kjellén L (2000). "Overexpression of different isoforms of glucosaminyl N-deacetylase/N-sulfotransferase results in distinct heparan sulfate N-sulfation patterns". Biochemistry. 39 (15): 4552–8. doi:10.1021/bi992524l. PMID 10758005.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• van den Born J, Pikas DS, Pisa BJ, et al. (2003). "Antibody-based assay for N-deacetylase activity of heparan sulfate/heparin N-deacetylase/N-sulfotransferase (NDST): novel characteristics of NDST-1 and -2". Glycobiology. 13 (1): 1–10. doi:10.1093/glycob/cwg011. PMID 12634318.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Duncan MB, Liu M, Fox C, Liu J (2006). "Characterization of the N-deacetylase domain from the heparan sulfate N-deacetylase/N-sulfotransferase 2". Biochem. Biophys. Res. Commun. 339 (4): 1232–7. doi:10.1016/j.bbrc.2005.11.142. PMID 16343444.