N-acetylneuraminate lyase

N-acetylneuraminate lyase
N-acetylneuramininate lyase tetramer, Aliivibrio salmonicida
Identifiers
EC no.	4.1.3.3
CAS no.	9027-60-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The enzyme N-acetylneuraminate lyase (EC 4.1.3.3) catalyzes the chemical reaction

N-acetylneuraminate ${\displaystyle \rightleftharpoons }$ N-acetyl-D-mannosamine + pyruvate

This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is N-acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming). Other names in common use include N-acetylneuraminic acid aldolase, acetylneuraminate lyase, sialic aldolase, sialic acid aldolase, sialate lyase, N-acetylneuraminic aldolase, neuraminic aldolase, N-acetylneuraminate aldolase, neuraminic acid aldolase, N-acetylneuraminic acid aldolase, neuraminate aldolase, N-acetylneuraminic lyase, N-acetylneuraminic acid lyase, NPL, NALase, NANA lyase, acetylneuraminate pyruvate-lyase, and N-acetylneuraminate pyruvate-lyase. This enzyme participates in aminosugars metabolism.

Structural studies

As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes 1F5Z, 1F6K, 1F6P, 1F73, 1F74, 1F7B, 1FDY, 1FDZ, 1HL2, and 1NAL.

References

• COMB DG, ROSEMAN S (1960). "The sialic acids. I. The structure and enzymatic synthesis of N-acetylneuraminic acid". J. Biol. Chem. 235: 2529–37. doi:10.1016/S0021-9258(19)76908-7. PMID 13811398.
• Schauer R (1982). "Advances in Carbohydrate Chemistry and Biochemistry Volume 40; Chapter = Chemistry, Metabolism, and Biological Functions of Sialic Acids". Adv. Carbohydr. Chem. Biochem. 40: 131–234. doi:10.1016/S0065-2318(08)60109-2. ISBN 978-0-12-007240-8. PMID 6762816.