Though Peña has been a regular in independent productions since 1996, his breakthrough performances came in two Best PictureOscar-winning Paul Haggis-penned films, Million Dollar Baby (2004) and Crash (2004). The former was directed by Clint Eastwood, and the latter was directed by Haggis. Though both films are critically acclaimed, Peña received attention for his particularly emotional performance in Crash. The following year, he appeared on the Golden Globe-winning series The Shield. He starred in Oliver Stone's film based on the September 11, 2001 attacks, World Trade Center. He also had a small role in Alejandro González Iñárritu's film Babel. This gives him the rare distinction of having appeared in three consecutive films nominated for the Best Picture Oscar.
In 2006, Peña starred in the HBO film Walkout as Sal Castro, a Mexican-American high school teacher who inspires a group of East L.A. high school students to fight for Chicano rights.
In 2015, Peña was a principal player of the ensemble cast for his role on board the Ares-III space-craft to Mars, in the award-winning Ridley Scott sci-film The Martian.
Peña starred in 12 Strong alongside Chris Hemsworth. He also starred in the 2018 remake of A Wrinkle in Time, where he played the main antagonist, The IT, in his human form (known as "Red").[12] In 2020, Peña took a turn as the mysterious and enigmatic Mr. Roarke in the critically panned prequel Fantasy Island.[13]
Television
In December 2017, it was reported that Peña had joined the cast of Narcos for its upcoming fourth season.[14] It was later revealed that the fourth season would be a new series, Narcos: Mexico, with Peña starring as DEA agent Kiki Camarena.[15]
Voice acting
Peña voiced the character Ricky in the FX animated comedy Chozen. In Turbo, he voiced Tito. He also provided vocals for the character Marguerite (in the episode "Hot Water") for the popular animated series American Dad!.
Music
In 2005, Peña formed the Los Angeles rock band Nico Vega, named after his mother, Nicolasa. He left the band in 2007 to concentrate on his acting career, but co-wrote the track "Beast", which reached No. 26 on the Billboard Hot Rock Songs Chart. Peña starred in a video created for Midlake's track "Bethel Woods", which premiered January 12, 2022. He returned with Nico Vega in December 2023.