Methanogen homoaconitase

Methanogen homoaconitase
Identifiers
EC no.	4.2.1.114
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Methanogen homoaconitase (EC 4.2.1.114, methanogen HACN) is an enzyme with systematic name (R)-2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate-forming).[1] This enzyme catalyses the following chemical reaction

(R)-2-hydroxybutane-1,2,4-tricarboxylate ${\displaystyle \rightleftharpoons }$ (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate (overall reaction)

(1a) (R)-2-hydroxybutane-1,2,4-tricarboxylate ${\displaystyle \rightleftharpoons }$ (Z)-but-1-ene-1,2,4-tricarboxylate + H₂O

(1b) (Z)-but-1-ene-1,2,4-tricarboxylate + H₂O ${\displaystyle \rightleftharpoons }$ (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate

This enzyme catalyses several reactions in the pathway of coenzyme-B biosynthesis in methanogenic archaea.

References

1. Drevland RM, Jia Y, Palmer DR, Graham DE (October 2008). "Methanogen homoaconitase catalyzes both hydrolyase reactions in coenzyme B biosynthesis". The Journal of Biological Chemistry. 283 (43): 28888–96. doi:10.1074/jbc.m802159200. PMC 2662002. PMID 18765671.

External links

• Methanogen+homoaconitase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)