The Mesostriatal system is a term sometimes used to identify the midbrain dopamine projections into the striatum and cortex. It has been described as a combination of the mesolimbic and nigrostriatal dopamine projections, and has been described as being partially asymmetric.[1]
Research
It has been referred to in the context of α-melanocyte stimulating hormones effect on dopamine activity in the mesostriatal system.[2] Research identifying cholinergic projections into these mesostriatal nuclei have been performed, revealing that the midbrain dopaminergic nuclei receive projections from the pedunculopontine tegmentum and laterodorsal pontine tegmentum.[3] The mesostriatal system has also been implicated in reward learning, coding predictions.[4] This anatomical classification has also been used in the context of parkinson research.[5]
^Roseberry, Aaron G.; Stuhrman, Katherine; Dunigan, Anna I. (1 September 2015). "Regulation of the mesocorticolimbic and mesostriatal dopamine systems by α-melanocyte stimulating hormone and agouti-related protein". Neuroscience and Biobehavioral Reviews. 56: 15–25. doi:10.1016/j.neubiorev.2015.06.020. ISSN1873-7528. PMID26116876. S2CID43619316.
^Zhou, Fu-Ming; Wilson, Charles; Dani, John A. (1 February 2003). "Muscarinic and nicotinic cholinergic mechanisms in the mesostriatal dopamine systems". The Neuroscientist. 9 (1): 23–36. doi:10.1177/1073858402239588. ISSN1073-8584. PMID12580337. S2CID8266496.
^Cools, A. R. (1 March 1990). "Role of neostriatal and mesostriatal or mesolimbic dopaminergic fibres in Parkinson's disease with and without dementia: prospects, concepts and facts". Yakubutsu, Seishin, Kodo = Japanese Journal of Psychopharmacology. 10 (1): 15–34. ISSN0285-5313. PMID2220127.