Mengla dianlovirus

Mengla dianlovirus
Virus classification Edit this classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Negarnaviricota
Class: Monjiviricetes
Order: Mononegavirales
Family: Filoviridae
Genus: Dianlovirus
Species:
Mengla dianlovirus
Synonyms
  • Mengla virus

Mengla dianlovirus (MLAV, also written Měnglà virus) is a type of filovirus identified in a Rousettus bat in Mengla County, Yunnan Province, China, and was first reported in January 2019.[1] It is classified in the same family as Ebolavirus and Marburgvirus.[2]

It is the only member of the genus Dianlovirus.[1] The name derives from 滇 (diān), the Chinese language abbreviation for Yunnan, added to "filovirus", the common name for Filoviridae.[1] Neither the species nor the genus are listed in the 2018 ICTV classification, as the virus was formally described after that report was released.[3] A formal proposal was submitted for the taxa in January 2019.[4]

MLAV proteins, including VP35 and VP40, inhibit host immune responses by interfering with interferon signaling, contributing to immune evasion similar to other filoviruses.[5] Like other filoviruses, Mengla virus utilizes the Niemann-Pick C1 (NPC1) receptor for cell entry, a trait that may facilitate cross-species transmission.[6]

References

  1. ^ a b c Yang, Xing-Lou; Tan, Chee Wah; Anderson, Danielle E.; Jiang, Ren-Di; Li, Bei; Zhang, Wei; Zhu, Yan; Lim, Xiao Fang; Zhou, Peng; Liu, Xiang-Ling; Guan, Wuxiang; Zhang, Libiao; Li, Shi-Yue; Zhang, Yun-Zhi; Wang, Lin-Fa; Shi, Zheng-Li (2019). "Characterization of a filovirus (Měnglà virus) from Rousettus bats in China". Nature Microbiology. 4 (3): 390–395. doi:10.1038/s41564-018-0328-y. PMID 30617348. S2CID 57574565.
  2. ^ "New bat-borne virus related to Ebola". Science Daily. January 7, 2019.
  3. ^ Virus Taxonomy: 2018 Release, International Committee on Taxonomy of Viruses, retrieved 2018-12-01
  4. ^ Wáng, Línfā; Shí, Zhènglì; Yáng, Xìnglóu; Kuhn, Jens H. "One (1) new genus including one (1) new species in the mononegaviral family Filoviridae". International Committee on Taxonomy of Viruses (ICTV). Retrieved 25 May 2019.[dead link‍]
  5. ^ Williams CG, Gibbons JS, Keiffer TR, Luthra P, Edwards MR, Basler CF (16 June 2020). "Impact of Měnglà Virus Proteins on Human and Bat Innate Immune Pathways". J Virol. 94 (13): e00191-20. doi:10.1128/JVI.00191-20. PMC 7307173. PMID 32295912.
  6. ^ Xie, Shi-Zhe; Yao, Ke; Li, Bei; Peng, Cheng; Yang, Xing-Lou; Shi, Zheng-Li (June 2024). "Development of a Měnglà virus minigenome and comparison of its polymerase complexes with those of other filoviruses". Virologica Sinica. 39 (3): 459–468. doi:10.1016/j.virs.2024.03.011. ISSN 1995-820X. PMC 11279764. PMID 38782261.


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