| | | | | | | | | | | | Medico di Potrone (1046–1102) |
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| | | | | | | | | | | | Bono di Potrone (1069–1123) |
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| | | | | | | | | | | | Bernardo di Potrone (1099–1147) |
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| | | | | | | | | | | | Giambuono de' Medici (1131–1192) |
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| | | | | | | | | | | | Chiarissimo de' Medici I (1167–1210) |
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| | | | | | | | | | | | Filippo di Chiarissimo de' Medici |
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| | | | | | | | | | | | Averardo de' Medici I (fl. 1280) |
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| | | | | | | | | | | | Averardo de' Medici II (1270–1319) |
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| | | | | | | | | | | | Salvestro de Medici (il Chiarissimo III) (1300–1346) | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Giovenco de' Medici (died 1320) |
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| | | | | | | | | | | | Averardo de' Medici III
(1320–1363) m. Jacopa Spini | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Giuliano de' Medici (d. 1377) |
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| | | | | | | | | | | | Giovanni di Bicci de' Medici
(1360–1429) m. Piccarda Bueri | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
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Antonio de' Medici (?–1398) | | Damian de' Medici (1389–1390) | | | | | | | | | Cosimo de' Medici (the Elder) (1389–1464) | | | | Contessina de' Bardi (ca.1390–1473) | | | | | | | | | | | | Lorenzo de' Medici (the Elder) (1395–1440) m. Ginevra Cavalcanti | | | | | | | Antonio de' Medici |
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Piero I de' Medici (the Gouty) (1416–1469) Lord of Florence | | | | | Lucrezia Tornabuoni (1425–1482) | | | | | | Carlo de' Medici (1430–1492) | | | | | | | Giovanni de' Medici (1421–1463) m. Ginevra degli Alessandrini | | | | | | | Francesco de' Medici (?–ca.1440) | | Pierfrancesco de' Medici (the Elder) (1431–1476) m. Laudomia Acciaioli | | | | | | | | |
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Giovanni de' Medici (ante 1444–1478) | | Maria de' Medici (1445–1472) m. Leonetto de' Rossi | | Bianca de' Medici (1445–1505) m. Guglielmo de' Pazzi | | Lucrezia de' Medici (Nannina) (1448–1493) m. Bernardo Rucellai | | Lorenzo de' Medici (the Magnificent) (1449–1492) Lord of Florence m.(1) Clarice Orsini | | Giuliano de' Medici (1453–1478) | | Cosimo de' Medici (1452–1461) | | | | | | Lorenzo the Popolano (1463–1503) Lord of Piombino m. Semiramide Appiani | | | | | Giovanni the Popolano (1467–1498) m. Caterina Sforza | | | Bernardetto de' Medici (died 1475) |
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Lucrezia de' Medici (1470–1553) m. Jacopo Salviati | | Piero II de' Medici (the Unfortunate) (1471–1503) Lord of Florence m. Alfonsina Orsini | | Maddalena de' Medici (1473–1528) m. Franceschetto Cybo | | Giovanni di Lorenzo de' Medici (1475–1521) Pope Leo X | | Luisa de' Medici (1477–1488) | | Contessina de' Medici (1478–1515) m. Piero Ridolfi | | Giuliano de' Medici (1479–1516) Duke of Nemours | | Giulio de' Medici (1478–1534) Pope Clement VII | | | | | Averardo de' Medici (1488–1495) | | | Ginevra de' Medici m. Giovanni degli Albizzi | | | | | | | | |
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| | | | | | | | | | | | | | | | | | | | | | | | | | | Ippolito de' Medici (1511–1535) Cardinal) | | | | | | Pierfrancesco de' Medici (the Younger) (1487–1525) m. Maria Soderini | | Laudomia de' Medici m. Francesco Salviati | | Vincenzo de' Medici | | | Lorenzo de' Medici |
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Giovanni Salviati (1490–1553) Cardinal | | | Lorenzo Salviati (1492–1539) | | | Lorenzo II de' Medici (1492–1519) Duke of Urbino | | Madeleine de La Tour (ca.1495–1519) | | Clarissa de' Medici (1493–1528) m. Filippo Strozzi | | Elena Salviati (1495–1552) m.(1) Pallavicino Pallavicino m.(2) Iacopo V Appiani | | | Battista Salviati (1498–1524) | | Luisa Salviati m. Sigismund de Luna | | | Bernardo Salviati (1508–1568) Cardinal | | | Maria Salviati (1499–1543) | | Lodovico de' Medici (Giovanni dalle Bande Nere) (1498–1526) | | | |
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| | Francesca Salviati m. Ottaviano de' Medici | | Piero Salviati | | | | | | | Piero Strozzi (1510–1558) | | Laudomia de' Medici (?–1559) | | Alamanno Salviati (1510–1571) | | Lorenzino de' Medici (Lorenzaccio) (1514–1548) | | Giuliano de' Medici (ca.1520–1588) Archbishop of Albi | | Roberto Strozzi (ca.1512–1566) | | Maddalena de' Medici (1523–1583) | | | | | | Ottaviano de' Medici (1482-1546) m. Francesca Salviati | |
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Alessandro Ottaviano de' Medici (1535–1605) Pope Leo XI | | | | | | | Alessandro de' Medici (the Moor) (1510–1537) Duke of Florence | | | Caterina de' Medici (1519–1589) | | | Henry II of France (1519–r.1547–1559) | | | | | | | | | | | | | | | | | | Cosimo I de' Medici (1519–1574) Grand Duke of Tuscany | |
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| | | | Bernadetto de' Medici | | Giulia de' Medici (ca.1535–ca.1588) | | Porzia de' Medici (1538–1565) | | Francis II of France (1544–r.1559–1560) | | | Charles IX of France (1550–r.1560–1574) | | | Henry III of France (1551–r.1574–1589) | | | Francis, Duke of Anjou (1555–1584) | | Francesco I de' Medici (1541–1587) Grand Duke of Tuscany | | Claude (1547–1575) m. Charles III of Lorraine | | | | |
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| Giulio de' Medici (ca.1533–1600) | | Alessandro de' Medici (1560–1606) | | | | | | Philip II of Spain (1527–r.1556–1598) | | Elisabeth of Valois (1545–1568) | | Margaret of Valois (1553–1615) | | Henry IV of France (1553–r.1589–1610) | | | | Marie de' Medici (1575–1642) | | Christina of Lorraine (1565–1637) | | Ferdinando I de' Medici (1549–1609) Grand Duke of Tuscany |
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Caterina de' Medici (?–1634) | | Cosimo de' Medici (ca.1550–ca.1630) | | Giuliano de' Medici | | | Philip III of Spain (1578–r.1598–1621) | | | | | | | | | | | Christine Marie (1606–1663) m. Victor Amadeus I of Savoy | | Nicolas Henri, Duke of Orléans (1607–1611) | | Gaston, Duke of Orléans (1608–1660) | | Henrietta Maria of France (1609–1669) m. Charles I of England |
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| | | | Angela/Angelica de' Medici (1608–1636) m. Pietro Altemps | | | | | | | Philip IV of Spain (1605–r.1621–1665) | | Elisabeth (1602–1644) | | Louis XIII of France (1601–r.1610–1643) | | Anne of Austria (1601–1666) | | Charles II of England (1630–r.1660–1685) | | Mary Henrietta Stuart (1631–1660) m. William II of Orange | | James II of England (1633–r.1685-88 –1701) |
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