She and her spouse were already related through the marriage of his sister, Elisabetta, to her brother, Carlo.[1][3] Francesco's first wife Agnese Visconti had been executed for infidelity in 1391.[4] Margherita and Francesco I were the parents of Gianfrancesco I the first Marquis of Mantua. Gianfrancesco married Paola Malatesta,[1] daughter of Malatesta IV, in 1409.
The network of related women Margherita Malatesta, Alda d'Este, and Elisabetta and Margherita Gonzaga are considered to have tied together the courts of Mantua, Ferrara, Rimini and Pesaro.[5] The Gonzaga family struck medals of Margherita.[6] Margherita brought the hereditary disease of rickets to the Gonzagas, which manifested itself periodically in the lords of Mantua until the 16th century. She died on February 28, 1399, and was interred in Church of San Francesco in Mantua, in the mausoleum of the Gonzagas.
^Lazzarini Is. "Gonzaga, Francesco". Dizionario Biografico degli Italiani — Volume 57 (2001) (in Italian). www.treccani.it. Archived from the original on 2016-03-04. Retrieved 8 May 2017.
^ abGiovanni Paccagnini; Maria Figlioli Paccagnini (1986). Palazzo Ducale of Mantua. Mantua: Electa.