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Manuel Dominguez (1803–1882) was a Californian rancher.

Manuel Domínguez may also refer to:

Manuel Domínguez (1868–1935), Vice President of Paraguay from 1902 to 1904
Manuel Jorge Domínguez (born 1962), Spanish cyclist
Manuel Domínguez González (born 1974), Spanish politician

This disambiguation page lists articles about people with the same name.
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