The album's title and themes originate from Khaled's recently raised profile in social media. In late 2015, Khaled became highly popular on Snapchat, sharing his advice that he calls his "keys to success", utilizing the 'key' emoji as a symbol of his knowledge.[3] The album's title is also a play on words, alluding simultaneously to the major mode and songs being performed in a major key. Some songs featured in this album, like "For Free" featuring Drake, have Khaled announcing the album name in the beginning of the song, shortly after announcing his record label, like in many other recent songs.
In an interview with DJ Whoo Kid, record producer Southside revealed that he was producing a song for DJ Khaled, Jay-Z and Future's single.[8] In an interview with Entertainment Weekly, DJ Khaled spoke about the album and revealing on who the guest appearances stated "I've got another record with me, Future, and Jay Z. I want to clarify and make sure everybody knows that I have two verses from Jay Z on this record with me and Future. Amongst other artists, me and Kanye West, we talking right now about making something special. Me and Rick Ross. Ross is definitely on the album. Lil Wayne, Big Sean, Chris Brown, August Alsina, Travis Scott, the list goes on."[9] He also hinted that he was going to collaborate with artists such as Mariah Carey and Drake on his Snapchat and Instagram.[7] DJ Khaled slated that the album would have no more than 14 songs.[10]
The official second single from Major Key, "I Got the Keys", was released on June 4, 2016. The song features guest appearances from American rappers Future and Jay-Z, with production by Southside, Jake One and G Koop.[13] The music video was released after the 2016 BET Awards.[14]
On July 22, 2016, DJ Khaled would premiered his third single from the album, "Holy Key" featuring Kendrick Lamar, Big Sean and Betty Wright, during episode 24 of his primetime radio show We The Best Radio on Beats 1 radio.[15]
Major Key received generally positive reviews from critics. At Metacritic, which assigns a normalized rating out of 100 to reviews from mainstream publications, the album received an average score of 67, based on 11 reviews.[18] Andy Kellman of AllMusic said, "The contrast between Khaled's all-positive demeanor and his facilitation of buccaneering misogyny is stark as ever here, most evident in tracks like "Work It" and "Pick These Hoes Apart"."[19] KC Orcutt of Consequence of Sound said, "As might be expected from a record this big with a rolodex this wide-ranging, Major Key is an absolutely mixed bag. Khaled utilizes full-speed-ahead intensity, big room trap, and syrupy R&B, all without leaving room to breathe. But then again, Khaled's presence unifies Major Key."[1] Nolan Feeney of Entertainment Weekly said, "His bottomless stock of anthemic crowd-pleasers may not be game-changing, but few albums this year have come preloaded with this many obvious singles."[20] Scott Glaysher of HipHopDX said, "There are instances on this album that do prove Khaled's worth as a Hip Hop orchestrator in terms of matching high profile rappers with quality beats but unfortunately, they come too few and far between."[22] Kris Ex of Pitchfork said, "Like all of his albums, Major Key is a mixed bag, fitting for a maestro who traffics in a blend of chest-thumping and humility that's both as comical as it is prophetic."[23]
Steve "Flash" Juon of RapReviews.com said, "If you're not expecting an hour of profound wisdom from start to finish this is an ideal late summer mixtape to ride around to."[25] A. Harmony of Exclaim! said, "It starts off deceptively strong, with standouts like "I Got the Keys", "Nas Album Done" and "For Free" all loaded near the beginning. But once the album advances past this bit of clever sequencing, it barely strikes a chord."[21] Michael G. Barilleaux of No Ripcord said, "The production on this album is bearable and more or less gets the job done, but is mostly composed of bothersome loops. This leaves the bulk of the work to the emcees. And quite frankly, some show up, and some most certainly do not."[28] Nathaniel Schwass of PopMatters said, "While Major Key proves that DJ Khaled is not simply a meme, Khaled swings too hard and misses too often with each attempt at a radio hit."[24] Christopher R. Weingarten of Rolling Stone said, "As with every Khaled LP, the end result is a blast in small doses but a little bludgeoning taken as a whole."[26] Matthew Ramirez of Spin said, "The problem with the fantasy of a major Khaled Album though, is that, like a summer blockbuster, Major Key is too front-loaded."[27]
In its home country of the United States, Major Key debuted at number one on the US Billboard 200, with 96,000 equivalent album units, marking Khaled's first number one album.[32] While it was the best-selling album of the week, selling 59,000 copies in its first week.[33] The album sales launch is DJ Khaled's second-biggest first week in his career, behind We the Best (2007).[32] In its second week, the album remained in the top ten at Billboard 200, fell to number seven, with 43,000 equivalent album units, it sold 12,000 copies.[34][35] On September 27, 2019, Major Key was certified platinum by the Recording Industry Association of America (RIAA).[2]