Brandeis was best known for her "Children of America" and "Children of All Lands" series of books. Most of the fictional stories included photographs taken by the writer, with child actors as the books' characters.
She was also a founder of The Little Players' Film Co., with offices in New York City and Chicago, which featured casts composed almost entirely of children. She wrote, directed, and financed her first feature film The Star Prince (1918), released in 1920 as Twinkle Twinkle Little Star. She produced and directed the film series Children of All Lands (1928/29), The Little Dutch Tulip Girl (1928/29), The Little Indian Weaver, and The Little Swiss Wood-Carver.[4]
In 1918, she married E. (Erving) John Brandeis, of Omaha's Brandeis department stores. They divorced on 24 April 1921, at which point she was living in Beverly Hills; she received a US$400,000 settlement.[5] She died in Gallup, New Mexico, of injuries suffered in an automobile accident two weeks earlier while she and her daughter Marie (b. 1920) were driving from New York to Los Angeles.