The Diego Sepúlveda Adobe was built overlooking Lupukngna and Genga from between 1817-1823[9][10] as an outpost "to watch over cattle and Indians." In 1827, missionaries considered whether to move their entire operation to the location.[7]
In 1935, archaeologists found evidence of a village along the Santa Ana River near contemporary Adams Avenue. It was found that villagers primarily subsisted on acorns, seeds, berries, small game, fish and shellfish, similar to surrounding Tongva villages. Shell mounds were also found.[5][11]
The Newland House Museum was identified as a likely site of the village. This is because the house was constructed on one of a few knolls in the area that rises above the Santa Ana River's floodplain. Numerous Tongva villages in the area were established on other similar knolls, making the location more probable. Additionally, several archaeological investigations have been done at the house since the 1930s, which have yielded various Tongva artifacts.[12][13]
A small residential street in Costa Mesa near the Diego Sepúlveda Adobe is named Lukup Lane in reference to the village.[14]