Prior to the band's formation, its eventual lead singer, Matt Lowell, began writing songs in New York City with the intention of forming a band. He later moved to Los Angeles where he met bassist and keyboardist, Crisanta Baker. He played her a demo for the song, "Loveless", and, soon after, she became the second member of the band. Guitarist Samuel Stewart - who is the son of David A. Stewart of Eurythmics and Siobhan Fahey of Bananarama - joined shortly after. The band soon began practicing in Lowell's backyard shed.[2][3] The "Loveless" demo, which Lowell had begun writing in 2012,[4] attracted the attention of Columbia Records and spurred the label to sign Lo Moon.[5] Sterling Laws later joined as their touring drummer.
In September 2017, Lo Moon was one of three acts added to NPR's inaugural Slingshot emerging artist series.[8][12] They also opened for Ride.[13][14] The following month, they opened for Phoenix on five dates in North America[15] and toured with London Grammar in the United Kingdom and Europe. That month, they also released a new single, "Thorns".[16] The band began headlining shows in November 2017, including sold-out stops at the Troubadour in Los Angeles[15][17] and at Rough Trade NYC.[18]
In January 2018, the band announced details of its self-titled debut album. The album was released on February 23, 2018 through Columbia Records, and produced by Chris Walla and François Tétaz.[19][20] The song "This Is It" peaked at number 6 on the BillboardAdult Alternative Songs chart that month,[21] and the band performed it (along with "Loveless") on Jimmy Kimmel Live on January 16.[19]
On November 28, 2018, the band announced that drummer Sterling Laws, previously a touring member of the band, was now a full band member.[22]
On July 16, 2024, the band announced that drummer Sterling Laws left the band to pursue other musical endeavors. [23]