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Seat vacant 1441–1448 (according to the Grand Duke of Moscow)
Isidore of Kiev, who was of Greek origin, submitted to the articles of the Bull of Union with the Greeks which united the Orthodox Church in Russia with the Latin Church. Following his acceptance of the Council of Florence, Isidore returned to Moscow in 1441 as a Rutheniancardinal. He was arrested by the Grand Prince of Moscow — Vasily II, and accused of apostasy. The Grand Duke deposed Isidore and in 1448 installed his own candidate as Metropolitan of Kiev — Jonah. This was carried out without the approval of Patriarch Gregory III of Constantinople. When Isidore died in 1458, the Orthodox dioceses within the territory of the Grand Duchy of Lithuania, including Kiev, were reorganized. The metropolitan see was moved to Vilnius, the capital of the Grand Duchy of Lithuania. A parallel succession to the title ensued between Moscow and Vilnius.
Metropolitans of Moscow and all Rus' (1448–1589)
The Grand Prince of Moscow voided the Union of Florence and imprisoned Metropolitan Isidore for some time. Following that incident, the Grand Prince removed Isidore from office and appointed his own man — Jonah. These decisions were not recognised by Patriarch Gregory III of Constantinople who continued to recognise Isidore as the canonical metropolitan. As a result, in 1448, Jonah unilaterally changed his title to "Metropolitan of Moscow and all Rus' " which was tantamount to a declaration of independence of the Church in eastern Rus' from the Patriarchate of Constantinople. All sixteen successive hierarchs of the Metropolis of Moscow and all Rus' were selected by the civil power and installed without the approval of Patriarchate of Constantinople. Successive patriarchs continued to recognize Isidore and his successors as hierarchs of the Metropolis of Kiev and all Rus'.
President of the Most Holy Synod. Stefan refused to sign the Synod's documents, did not attend its meetings. Peter I apparently appointed him only to give a certain sanction to the new institution.