Most at-bats: 9 – Alfredo Griffin (October 4, 1980 vs. Boston Red Sox) (17 inning game), Jose Reyes (August 10, 2014 vs. Detroit Tigers) (19 inning game)
Most at-bats (9 inning game): 7 – Ben Revere (September 30, 2015 vs. Baltimore Orioles)
Most runs scored: 5 – 5 tied for lead, most recently Lourdes Gurriel Jr. (September 12, 2021 vs. Baltimore Orioles)
Most doubles: 4 – Dámaso García (June 27, 1986 vs. New York Yankees), Shannon Stewart (July 18, 2000 vs. New York Mets), Alex Ríos (August 17, 2008 vs. Boston Red Sox)
Most triples: 2 – 11 tied for lead, most recently Alex Ríos (April 27, 2005 vs. Tampa Bay Devil Rays)
Most home runs: 4 – Carlos Delgado (Sept 25, 2003 vs. Tampa Bay Devil Rays)
Most total bases: 16 – Carlos Delgado (Sept 25, 2003 vs. Tampa Bay Devil Rays)
Most RBI: 9 – Roy Howell (Sept 10, 1977 vs. New York Yankees), Edwin Encarnación (August 29, 2015 vs. Detroit Tigers)
Most strikeouts: 6 – Alex Gonzalez (Sept 9, 1998 vs. Cleveland Indians)
Most walks: 5 – Melky Cabrera (August 10, 2014 vs. Detroit Tigers)
Most stolen bases: 4 – Dámaso García (April 25, 1984 vs. Oakland Athletics), Dave Collins (August 5, 1984 vs. Baltimore Orioles), Roberto Alomar (June 8, 1991 vs. Baltimore Orioles), Otis Nixon (August 14, 1996 vs. Boston Red Sox), Rajai Davis (July 28, 2013 vs. Houston Astros)
Most hit-by-pitch: 3 – Reed Johnson (April 16, 2005 vs. Texas Rangers), (April 7, 2006 vs. Tampa Bay Devil Rays), (April 29, 2006 vs. New York Yankees)
Most times-on-base: 8 – Melky Cabrera (August 10, 2014 vs. Detroit Tigers)
Pitching leaders
Most innings: 12 – Jesse Jefferson (May 23, 1978 vs. Boston Red Sox), Dave Stieb (May 17, 1980 vs. Oakland Athletics)
Most innings (reliever): 7.1 – Mike Willis (Sept 27, 1977 vs. Boston Red Sox)
Most hits: 14 – Josh Towers (May 27, 2005 vs. Minnesota Twins)
Most runs: 13 – David Wells (August 20, 1992 vs. Milwaukee Brewers)
Most earned runs: 13 - David Wells (August 20, 1992 vs. Milwaukee Brewers)
Most unearned runs: 10 - Dave Stewart (May 19, 1993 vs. Boston Red Sox)
Most home runs: 5 – Pat Hentgen (twice) (May 26, 1995 vs. Cleveland Indians), (June 25, 1997 vs. Boston Red Sox)
Most strikeouts: 18 – Roger Clemens (August 25, 1998 vs. Kansas City Royals)
Most walks: 9 – Jesse Jefferson (June 18, 1977 vs. Baltimore Orioles), Jim Clancy (August 30, 1984 vs. Chicago White Sox), Tom Candiotti (August 8, 1991 vs. Detroit Tigers), Pat Hentgen (July 15, 1995 vs. Seattle Mariners), Chris Carpenter (August 16, 1999 vs. Seattle Mariners)
Most hit batsmen: 3 – David Wells (April 12, 1992 vs. Baltimore Orioles), Chris Michalak (June 6, 2001 vs. Tampa Bay Devil Rays), Mark Buehrle (October 2, 2015 vs. Tampa Bay Rays)
Most wild pitches: 4 – John Cerutti (July 3, 1986 vs. Boston Red Sox)
Most strikeouts by a pitcher in his Blue Jays debut: 11 – David Price (August 3, 2015 vs Minnesota Twins)
Reliever striking out the side in extra innings with bases loaded: Jesse Carlson vs. Texas Rangers (April 16, 2008) – Top of 11th inning. Overall result – Blue Jays loss (7-5 in the 14th)
Four strikeouts in one extra inning: Steve Delabar vs. Chicago White Sox (August 13, 2012) – Top of 10th inning. Overall result – Blue Jays win (3–2 in the 11th), Mike Bolsinger vs. Boston Red Sox (July 18, 2017) – Bottom of 13th inning. Overall result – Blue Jays loss (5–4 in the 15th)
50-home run season: José Bautista (2010 season, season total 54)