Lauren V. Wood

Lauren V. Wood
Alma mater


Scientific career
Fields
  • Therapeutic Vaccines
  • HPV
  • Hepatitis C
  • HIV
Institutions

Lauren V. Wood is an American allergist, immunologist, and staff physician[1] at the National Cancer Institute (NCI) at the National Institutes of Health (NIH) in Bethesda, Maryland, where she has served as a principal investigator.[2] She is known for conducting studies of vaccines for cancer,[3] Human papillomavirus (HPV), Hepatitis C, and HIV[4] especially for use with children, teens and young adults.[5] She holds the rank of captain in the U.S. Public Health Service (PHS).

Education

Wood earned a B.A. degree in biology from Oberlin College and in 1984 received her M.D. degree from Duke University School of Medicine.[1][6] She completed a combined residency in internal medicine and pediatrics at Baylor College of Medicine Affiliated Hospitals in Houston, Texas.[1] She became board certified in both specialties.[1]

Career

Wood's clinical research interests include therapeutic vaccines and immune-based therapies for cancer and HIV infection, as well as research on other chronic viral infections such as (HPV) and hepatitis C.[7] She also conducts investigations of HIV and HPV transmission and associated risk behaviors.

Wood was awarded a fellowship at the National Institute of Allergy and Infectious Diseases (NIAID) and spent two years in the laboratory of now NIAID-director Anthony S. Fauci, M.D., where she conducted investigations of HIV-specific cellular and humoral immune responses. She then worked for a year with NIAID's Henry Masur, M.D. and H. Clifford Lane, M.D. in that Institute's HIV/AIDS Clinical Research Program.

Lauren Wood was the keynote speaker for the event, “Meet the Faces of Clinical Research: Beyond Inclusion,” co-sponsored by NIH's Office of Research on Women's Health and FDA's Office on Women's Health. May 14, 2015

In 1992, she was recruited to the NCI by Philip A. Pizzo, M.D. She served as a senior staff member of the NCI Pediatric HIV Working Group, first under Pizzo and subsequently under Robert Yarchoan, M.D. In 1994, she was promoted to Senior Surgeon.[8] At NCI, her clinical research focused on the investigation of antiretroviral agents and immune-based therapies in HIV-infected children, adolescents, and young adults, including the initial studies of lamivudine (3TC) and ritonavir that led to FDA approval for use in children. Wood also conducted studies of recombinant IL-2, HIV therapeutic vaccines and adherence to antiretroviral treatment. With other NCI colleagues, Wood also conducted investigations of the infectious, malignant, and psychosocial complications of pediatric HIV disease.[6] In 2005, Wood joined the newly formed the Vaccine Branch at NCI and was charged with developing a clinical translational research program, which she now heads.

At the NCI, she is responsible for the bench-to-bedside clinical translation and implementation of in-human studies investigating novel vaccine platforms and immune-based therapies for cancer and HIV infection.[6][9]

Wood's research extends to investigations of the TCRγ-alternative reading frame protein (TARP) peptide cancer vaccine in prostate cancer patients with PSA biochemical recurrence, a form of immunotherapy discovered by NCI veteran investigator Dr. Ira Pastan. A novel and potentially promising is the TARP is found in more than 90 percent of prostate cancers and about 50 percent of breast cancers.[10] Her work and research has been published in the Annals of Internal Medicine,[11] The Pediatric Infectious Disease Journal,[12] AIDS and Behavior,[13] The Archives of Dermatology,[14] The Journal of Clinical Microbiology,[15] The Expert Review of Vaccines,[16] Seminars in Oncology,[17] The American Journal of Roentgenology,[18] Blood,[19] The Journal of Immunology,[20] AIDS Patient Care and STDs,[21] The Journal of Acquired Immune Deficiency Syndromes,[22] Mitochondrion,[23] The Annals of the New York Academy of Sciences,[24] AIDS Care,[25] The Journal of Translational Medicine,[26] Molecular Therapy,[27] and others. In addition to publishing in peer-reviewed journals, she has also served as a reviewer for the Journal of Pediatrics and as an associate editor for Clinical and Diagnostic Laboratory Immunology.[8]

Honors

In addition to authoring numerous scientific publications and presenting her research at national and international scientific meetings, Wood has served on multiple FDA, White House, and other interagency advisory, review and data safety monitoring committees.[8] She is assistant professor at the Uniformed Services University of the Health Sciences (USUHS). She is a member of the board of directors of the NIH Children's Inn.[28][29]

References

  1. ^ a b c d "Lauren V. Wood, M.D." (PDF). Ccr.cancer.gov. 2014-08-12. Retrieved 2015-11-17.
  2. ^ Jackson, Cynthia L.; Nunn, Eleanor (2003). Historically Black Colleges and Universities: A Reference Handbook. ABC-CLIO, Inc. p. 47. ISBN 978-1851094226.
  3. ^ Garnett, Carla (2013-02-15). "For MLK Program, Wood Conveys 'Passion for Science of Treating Patients' – The NIH Record –". Nihrecord.nih.gov. Retrieved 2015-11-17.
  4. ^ James, Thomas (26 January 2015). "NIH Clinical Trial Aims to Stop Aggressive Tumors". WUSA. Retrieved 18 November 2015.
  5. ^ "NCI Visuals Online: Image Details". visualsonline.cancer.gov. Retrieved 2015-11-19.
  6. ^ a b c "2004 Biomedical Science Careers Student Conference" (PDF). Bscp.org. Archived from the original (PDF) on 2015-09-23. Retrieved 2015-11-17.
  7. ^ "Lauren V. Wood, MD". Demystifying Medicine. NIH. Retrieved 18 November 2015.
  8. ^ a b c "Adolescents and AIDS: Millennium Milestones". NIH Clinical Center Archive. 2000. Retrieved 18 November 2015.
  9. ^ "Inside NCI: A Conversation with Dr. Lauren Wood about Cancer". Retrieved 18 November 2015.
  10. ^ Garnett, Carla (2013-02-15). "For MLK Program, Wood Conveys 'Passion for Science of Treating Patients' – The NIH Record – February 15, 2013". Nihrecord.nih.gov. Retrieved 2015-11-17.
  11. ^ Miller, Kirk D.; Cameron, Miriam; Wood, Lauren V.; Dalakas, Marinos C.; Kovacs, Joseph A. (2000-08-01). "Lactic Acidosis and Hepatic Steatosis Associated with Use of Stavudine: Report of Four Cases". Annals of Internal Medicine. 133 (3): 192–196. doi:10.7326/0003-4819-133-3-200008010-00010. ISSN 0003-4819. PMID 10906833.
  12. ^ Martin, Staci; Elliott-DeSorbo, Deborah K.; Wolters, Pamela L.; Toledo-Tamula, Mary Anne; Roby, Gregg; Zeichner, Steve; Wood, Lauren V. (2007). "Patient, Caregiver and Regimen Characteristics Associated With Adherence to Highly Active Antiretroviral Therapy Among HIV-Infected Children and Adolescents". The Pediatric Infectious Disease Journal. 26 (1): 61–67. doi:10.1097/01.inf.0000250625.80340.48. PMID 17195708. S2CID 148932.
  13. ^ Wiener, Lori S.; Battles, Haven B.; Wood, Lauren V. (2006-09-21). "A Longitudinal Study of Adolescents with Perinatally or Transfusion Acquired HIV Infection: Sexual Knowledge, Risk Reduction Self-efficacy and Sexual Behavior". AIDS and Behavior. 11 (3): 471–478. doi:10.1007/s10461-006-9162-y. ISSN 1090-7165. PMC 2408713. PMID 17028994.
  14. ^ Toro, Jorge R.; Wood, Lauren V.; Patel, Nitin K.; Turner, Maria L. (2000-08-01). "Topical cidofovir: A novel treatment for recalcitrant molluscum contagiosum in children infected with human immunodeficiency virus 1". Archives of Dermatology. 136 (8): 983–985. doi:10.1001/archderm.136.8.983. ISSN 0003-987X. PMID 10926733.
  15. ^ Bodaghi, Sohrab; Wood, Lauren V.; Roby, Gregg; Ryder, Celia; Steinberg, Seth M.; Zheng, Zhi-Ming (2005-11-01). "Could Human Papillomaviruses Be Spread through Blood?". Journal of Clinical Microbiology. 43 (11): 5428–5434. doi:10.1128/JCM.43.11.5428-5434.2005. ISSN 0095-1137. PMC 1287818. PMID 16272465.
  16. ^ Arlen, Philip M.; Wood, Lauren V. (2012-01-01). "Prostate cancer vaccines: moving therapeutic vaccination forward in the post-Provenge™ era". Expert Review of Vaccines. 11 (3): 287–302. doi:10.1586/erv.11.183. ISSN 1476-0584. PMID 22380822. S2CID 21408417.
  17. ^ Berzofsky, Jay A.; Terabe, Masaki; Wood, Lauren V. (2012). "Strategies to Use Immune Modulators in Therapeutic Vaccines Against Cancer". Seminars in Oncology. 39 (3): 348–357. doi:10.1053/j.seminoncol.2012.02.002. PMC 3356566. PMID 22595057.
  18. ^ Patsalides, Athos D.; Wood, Lauren V.; Atac, Gokce K.; Sandifer, Eileen; Butman, John A.; Patronas, Nicholas J. (2002-10-01). "Cerebrovascular Disease in HIV-Infected Pediatric Patients: Neuroimaging Findings". American Journal of Roentgenology. 179 (4): 999–1003. doi:10.2214/ajr.179.4.1790999. ISSN 0361-803X. PMID 12239054.
  19. ^ Fry, Terry J.; Connick, Elizabeth; Falloon, Judith; Lederman, Michael M.; Liewehr, David J.; Spritzler, John; Steinberg, Seth M.; Wood, Lauren V.; Yarchoan, Robert (2001-05-15). "A potential role for interleukin-7 in T-cell homeostasis". Blood. 97 (10): 2983–2990. doi:10.1182/blood.V97.10.2983. ISSN 0006-4971. PMID 11342421. S2CID 9325365.
  20. ^ Wang, Jing; Shirota, Yuko; Bayik, Defne; Shirota, Hidekazu; Tross, Debra; Gulley, James L.; Wood, Lauren V.; Berzofsky, Jay A.; Klinman, Dennis M. (2015-05-01). "Effect of TLR Agonists on the Differentiation and Function of Human Monocytic Myeloid-Derived Suppressor Cells". The Journal of Immunology. 194 (9): 4215–4221. doi:10.4049/jimmunol.1402004. ISSN 0022-1767. PMC 4402268. PMID 25825448.
  21. ^ Wiener, Lori; Riekert, Kristin; Ryder, Celia; Wood, Lauren V. (2004-09-01). "Assessing Medication Adherence in Adolescents with HIV When Electronic Monitoring Is Not Feasible". AIDS Patient Care and STDs. 18 (9): 527–538. doi:10.1089/apc.2004.18.527. ISSN 1087-2914. PMID 15630773.
  22. ^ Martin, Staci; Wolters, Pamela L; Calabrese, Sarah K; Toledo-Tamula, Mary Anne; Wood, Lauren V; Roby, Gregg; Elliott-DeSorbo, Deborah K (2007). "The Antiretroviral Regimen Complexity Index". Journal of Acquired Immune Deficiency Syndromes. 45 (5): 535–544. doi:10.1097/qai.0b013e31811ed1f1. PMID 17589371. S2CID 19356846.
  23. ^ Mukhopadhyay, Abhijit; Wei, Baoxian; Zullo, Steven J.; Wood, Lauren V.; Weiner, Henry (2002-10-01). "In vitro evidence of inhibition of mitochondrial protease processing by HIV-1 protease inhibitors in yeast: a possible contribution to lipodystrophy syndrome". Mitochondrion. 1 (6): 511–518. doi:10.1016/S1567-7249(02)00042-9. PMID 16120303.
  24. ^ Gonzalez, Corina E.; Samakoses, Rudi; Boler, Anne Marie; Hill, Suvimol; Wood, Lauren V. (2000-11-01). "Lymphoid Interstitial Pneumonitis in Pediatric AIDS: Natural History of the Disease". Annals of the New York Academy of Sciences. 918 (1): 358–361. doi:10.1111/j.1749-6632.2000.tb05506.x. ISSN 1749-6632. PMID 11131724. S2CID 37750346.
  25. ^ Calabrese, Sarah K.; Martin, Staci; Wolters, Pamela L.; Toledo-Tamula, Mary A.; Brennan, Tara L.; Wood, Lauren V. (2012-09-01). "Diagnosis disclosure, medication hiding, and medical functioning among perinatally infected, HIV-positive children and adolescents". AIDS Care. 24 (9): 1092–1096. doi:10.1080/09540121.2012.699670. ISSN 0954-0121. PMC 3428222. PMID 22799616.
  26. ^ Stroncek, David F.; Fellowes, Vicki; Pham, Chauha; Khuu, Hanh; Fowler, Daniel H.; Wood, Lauren V.; Sabatino, Marianna (2014-09-17). "Counter-flow elutriation of clinical peripheral blood mononuclear cell concentrates for the production of dendritic and T cell therapies". Journal of Translational Medicine. 12 (1): 241. doi:10.1186/s12967-014-0241-y. ISSN 1479-5876. PMC 4173057. PMID 25223845.
  27. ^ Castiello, Luciano; Sabatino, Marianna; Zhao, Yingdong; Tumaini, Barbara; Ren, Jiaqiang; Ping, Jin; Wang, Ena; Wood, Lauren V.; Marincola, Francesco M. (2013-02-01). "Quality Controls in Cellular Immunotherapies: Rapid Assessment of Clinical Grade Dendritic Cells by Gene Expression Profiling". Molecular Therapy. 21 (2): 476–484. doi:10.1038/mt.2012.89. ISSN 1525-0016. PMC 3594020. PMID 23147403.
  28. ^ "Leadership | The Children's Inn at NIH". Childrensinn.org. Retrieved 2015-11-17.
  29. ^ "Association Launches Children's Inn Endowment – The NIH Record -June 13, 2008". Nihrecord.nih.gov. 2008-06-13. Retrieved 2015-11-17.