LRRFIP1

LRRFIP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4H22
Identifiers
Aliases	LRRFIP1, FLAP-1, FLAP1, FLIIAP1, GCF-2, GCF2, HUFI-1, TRIP, leucine rich repeat (in FLII) interacting protein 1, LRR binding FLII interacting protein 1
External IDs	OMIM: 603256; MGI: 1342770; HomoloGene: 48301; GeneCards: LRRFIP1; OMA:LRRFIP1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.3 Start 237,627,587 bp[1] End 237,813,682 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 D Start 90,998,737 bp[2] End 91,128,944 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla endothelial cell cardia nipple pylorus visceral pleura superior surface of tongue buccal mucosa cell mucosa of pharynx pericardium Top expressed in secondary oocyte zygote endothelial cell of lymphatic vessel conjunctival fornix granulocyte primary oocyte urothelium hair follicle transitional epithelium of urinary bladder lacrimal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding double-stranded RNA binding protein binding protein homodimerization activity cadherin binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component plasma membrane cytoskeleton nucleus cytoplasm cytosol Biological process regulation of transcription by RNA polymerase II negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated positive regulation of type I interferon production transcription, DNA-templated negative regulation of transcription by RNA polymerase II positive regulation of NF-kappaB transcription factor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9208 16978 Ensembl ENSG00000124831 ENSMUSG00000026305 UniProt Q32MZ4 Q3UZ39 RefSeq (mRNA) NM_001137550 NM_001137551 NM_001137552 NM_001137553 NM_004735 NM_001111311 NM_001111312 NM_008515 NM_001310732 RefSeq (protein) NP_001131022 NP_001131023 NP_001131024 NP_001131025 NP_004726 NP_001104781 NP_001104782 NP_001297661 NP_032541 Location (UCSC) Chr 2: 237.63 – 237.81 Mb Chr 1: 91 – 91.13 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Leucine-rich repeat flightless-interacting protein 1 is a protein that in humans is encoded by the LRRFIP1 gene.[5][6][7][8]

Interactions

LRRFIP1 has been shown to interact with FLII.[6][9]

References

1. GRCh38: Ensembl release 89: ENSG00000124831 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026305 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Reed AL, Yamazaki H, Kaufman JD, Rubinstein Y, Murphy B, Johnson AC (Sep 1998). "Molecular cloning and characterization of a transcription regulator with homology to GC-binding factor". J Biol Chem. 273 (34): 21594–602. doi:10.1074/jbc.273.34.21594. PMID 9705290.
6. Liu YT, Yin HL (May 1998). "Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies". J Biol Chem. 273 (14): 7920–7. doi:10.1074/jbc.273.14.7920. PMID 9525888.
7. Suriano AR, Sanford AN, Kim N, Oh M, Kennedy S, Henderson MJ, Dietzmann K, Sullivan KE (Oct 2005). "GCF2/LRRFIP1 represses tumor necrosis factor alpha expression". Mol Cell Biol. 25 (20): 9073–81. doi:10.1128/MCB.25.20.9073-9081.2005. PMC 1265793. PMID 16199883.
8. "Entrez Gene: LRRFIP1 leucine rich repeat (in FLII) interacting protein 1".
9. Fong KS, de Couet HG (Jun 1999). "Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system". Genomics. 58 (2): 146–57. doi:10.1006/geno.1999.5817. PMID 10366446.

Further reading

• Wilson SA, Brown EC, Kingsman AJ, Kingsman SM (1998). "TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I". Nucleic Acids Res. 26 (15): 3460–7. doi:10.1093/nar/26.15.3460. PMC 147727. PMID 9671805.
• Khachigian LM, Santiago FS, Rafty LA, Chan OL, Delbridge GJ, Bobik A, Collins T, Johnson AC (1999). "GC factor 2 represses platelet-derived growth factor A-chain gene transcription and is itself induced by arterial injury". Circ. Res. 84 (11): 1258–67. doi:10.1161/01.res.84.11.1258. PMID 10364563.
• Fong KS, de Couet HG (1999). "Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system". Genomics. 58 (2): 146–57. doi:10.1006/geno.1999.5817. PMID 10366446.
• Rikiyama T, Curtis J, Oikawa M, Zimonjic DB, Popescu N, Murphy BA, Wilson MA, Johnson AC (2003). "GCF2: expression and molecular analysis of repression". Biochim. Biophys. Acta. 1629 (1–3): 15–25. doi:10.1016/s0167-4781(03)00156-8. PMID 14522076.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.