LILRB5

LILRB5
Identifiers
Aliases	LILRB5, CD85C, LIR-8, LIR8, leukocyte immunoglobulin like receptor B5
External IDs	OMIM: 604814; HomoloGene: 134027; GeneCards: LILRB5; OMA:LILRB5 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.42 Start 54,249,421 bp[1] End 54,257,301 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen thymus subcutaneous adipose tissue right adrenal cortex left adrenal gland left adrenal cortex placenta duodenum right coronary artery gastric mucosa n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transmembrane signaling receptor activity Cellular component integral component of membrane membrane Biological process defense response cell surface receptor signaling pathway adaptive immune response immune system process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10990 n/a Ensembl ENSG00000274311 ENSG00000278437 ENSG00000273991 ENSG00000277414 ENSG00000105609 n/a n/a UniProt O75023 n/a RefSeq (mRNA) NM_001081442 NM_001081443 NM_001304457 NM_006840 n/a RefSeq (protein) NP_001074911 NP_001074912 NP_001291386 NP_006831 n/a Location (UCSC) Chr 19: 54.25 – 54.26 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Leukocyte immunoglobulin-like receptor subfamily B member 5 is a protein that in humans is encoded by the LILRB5 gene.[3][4]

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Several other LIR subfamily B receptors are expressed on immune cells where they bind to MHC class I molecules on antigen-presenting cells and inhibit stimulation of an immune response. Multiple transcript variants encoding different isoforms have been found for this gene.[4]

References

1. ENSG00000278437, ENSG00000273991, ENSG00000277414, ENSG00000105609 GRCh38: Ensembl release 89: ENSG00000274311, ENSG00000278437, ENSG00000273991, ENSG00000277414, ENSG00000105609 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Borges L, Hsu ML, Fanger N, Kubin M, Cosman D (Apr 1998). "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules". J Immunol. 159 (11): 5192–6. doi:10.4049/jimmunol.159.11.5192. PMID 9548455.
4. "Entrez Gene: LILRB5 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5".

Further reading

• Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.