Kano's music activities began in 2010 when she began uploading songs on the Japanese video-sharing website Nicovideo.[2] In 2015, she made her debut as a major artist with the release of her single "Stella-rium" on May 20;[3][4] the title song is used as the opening theme of the anime series Wish Upon the Pleiades.[5] Her second single, "Dear Brave" (ディアブレイブ), was released on November 18, 2015;[6] the title song was used as the first ending theme of the anime series Heavy Object.[7]
Kano released her first major album, Nowhere, on May 11, 2016.[8] Her third single, "Nameless", was released on September 7, 2016,[9] with the title track being used as the ending theme of the anime series Alderamin on the Sky.[10] Her fourth single "Day by Day" was released on May 24, 2017;[11] the title song is used as the ending theme of the anime series Sword Oratoria.[12] Her second album, Alstroemeria (アルストロメリア), was released on December 20, 2017.[13]
In 2018, it was announced that she would provide the voice bank for the Japanese version of the Chinese VocaloidLuo Tianyi.[14] On December 19, 2018, she released her third album, Rye.[15]
On September 25, 2019, Kano released the mini-album Itsuka no Yakusoku o Kimi ni (いつかの約束を君に).[16] This was followed by the release of the single "Hikari no Michishirube" (光の道標) on November 27, 2019;[17] the title track was used as the ending theme of the anime series Azur Lane.[18]
In 2020, Kano announced that she would debut as a Virtual YouTuber, with her 3D image being based on an avatar called "Bambi" that she has used on various media such as official artwork.[19] This was followed by the release of her fourth album, Yuanfen, on March 4, 2020.[20] She released the single "Nadamesukashi Negotiation" (なだめスかし Negotiation) on September 2, 2020;[21] a duet version with voice actress Naomi Ōzora is used as the opening theme of the anime series Uzaki-chan Wants to Hang Out!.[22]