On January 10, 2010, a grenade thrown at the tombs of Francis Joseph McSorley and Benjamin de Jesus, two former bishops, caused no injuries but shattered the windows.[3] The blast occurred an hour before a mass was scheduled to be celebrated. There were no injuries.[4]
On May 20, 2010, a grenade exploded in front of the cathedral at 9:30 in the evening. The cathedral suffered minor damage.[5] There were no reported fatalities or injuries.[6]
On January 27, 2019, the cathedral was bombed during a mass, killing at least 18 people and injuring 82 others.[7] The Islamic State claimed responsibility for the attack.[8]
The church building was repaired following the attacks. It was reconsecrated in July 2019.[9]
On August 24, 2020, two bombings occurred in Jolo, resulting in the deaths of seven soldiers, six civilians, one police officer and a bomber, while 75 other people were wounded. One of the two attacks was carried out by a female suicide bomber near the cathedral.[10]