John Neoptolemos

John P Neoptolemos
John P. Neoptolemos in 2021
Born
Pano Zodeia, Cyprus
EducationChurchill College, Cambridge, University of London, UCSD, University of Paris, University of Ulm
Known forEuropean Study Group for Pancreatic Cancer Research (ESPAC)
Medical career
ProfessionSurgeon
InstitutionsUniversity of Birmingham (Dudley Road Hospital), (Queen Elizabeth Hospital), Liverpool University, University of Heidelberg (University Hospital Heidelberg)
Sub-specialtiesGeneral surgery, Oncology
ResearchPancreatic disease, Pancreatic cancer, Pancreatitis

John P. Neoptolemos is a British surgeon and professor who specialised in pancreas research.[1][2] His specific areas of research are diagnosis,[3] biological predictors of treatment response[4][5] and therapies of pancreatic cancer[6][7][8] as well as acute, chronic, and hereditary pancreatitis. Neoptolemos was a British Department of Health Platinum Award holder from 2004.[9] He was elected a Member of the Academia Europaea in 2019.[10]

Early life, education, career

Neoptolemos was born in Pano Zodhia, Cyprus and raised in London. He graduated from the University of Cambridge (Churchill College) (1970-1973), and at Guy's Hospital, London (1973-1976). Neoptolemos completed his academic and clinical training in Leicester under the tutelage of Professor Sir Peter Bell,[11][12] being awarded a Doctorate in Medicine in 1986 for his thesis "Effect of surgery on monocyte function in patients with colorectal cancer".[13] During surgical training in Ulm he met Markus Büchler, together setting up the European Study for Pancreas Cancer Research (ESPAC)[14] later.

After appointments at the University of Birmingham, Neoptolemos was elected Chair of Surgery of Liverpool University and Head of Department of Surgery in 1996[15][16] to focus on pancreas disease research together with Professor Ole Petersen for the University,[17][18] and to develop the surgical services of the Royal Liverpool University Hospital.[19] Neoptolemos became the director of the newly established Liverpool Clinical Trial Unit (LCTU)[20] from 1996 and the chairman of the Pancreas Tumour Multi-Disciplinary Team at the Royal Liverpool University Hospital from 2001.[21] Neoptolemos and Petersen established the National Institutes of Health Research (NIHR) Pancreas Biomedical Research Unit from 2007, renewed again in 2012.[19] In 2005 he became head of the new School of Cancer Studies.[22] From 2007 he became the director of the Cancer Research UK Liverpool Cancer Trials Unit.[23] Neoptolemos was co-director of the CRUK and NIHR Liverpool Experimental Cancer Centre from 2007 until 2012 and from then the director of the LCTU GCP Labs as well as the director the CRUK from 2011 until 2013.[24] The Cancer Research UK Liverpool Centre received the Freedom of the City of Liverpool[25][26] on 8 February 2012. In 2014 the LCTU Cancer Research UK Liverpool Cancer Trials Unit received accreditation as National Cancer Research Institute (NCRI) Cancer Trials Unit.[20] The associated Pancreas Unit became the Health Services Journal National Award Winner in 2013.[27]

National and international scientific role

Neoptolemos was the Clinical Chair for the NICE Guidelines on Pancreatic Cancer (2015-2017).[28] John Neoptolemos has been Secretary and President of the European Pancreas Club (EPC),[29] as well as President of the Pancreatic Society of Great Britain and Ireland[30] and the International Association of Pancreatology[31] (IAP).[32] As IAP President he developed the first IAP Guidelines in 2003 – on acute pancreatitis.[33] Neoptolemos received international recognition including the Lifetime Achievement Award of the EPC[34] (2013); the Ruth Brufsky Award for Pancreas Cancer Research[35] (2017); and the Henry Lynch Award for Inherited Pancreas Diseases[36] (2018).

Scientific merits

In 1989 Neoptolemos was the founder of the European Study for Pancreas Cancer Research (ESPAC)[37][38] that has led the way for internationally collaborative pancreas cancer trials (ESPAC 1-4 trials[39][40][41]). The ESPAC-1 trial was the first trial to establish the benefit of adjuvant treatment in pancreatic cancer favoring chemotherapy[42] rather than chemoradiotherapy.[43][44] In 1997 he established the European Registry of Hereditary Pancreatitis and Pancreatic Cancer (EUROPAC)[45][46] for the study of genetic pancreatic diseases. In 2005 Neoptolemos co-founded the International Study Group for Pancreas Surgery (ISGPS) with Markus Büchler (Ulm) and others.[47]

Awards and honors (selection)

  • The Lord Smith Medal, Pancreatic Society of Great Britain and Ireland 1987[48]
  • Honorary Fellow of the German Society of Surgery 2012[49]
  • Freedom of the City of Liverpool as Director Cancer Research UK Liverpool Centre 2012[26]
  • Lifetime Achievement Award, European Pancreatic Club 2013[34]
  • Ruth Brufsky Award for Pancreas Cancer Research 2017[35]
  • Henry Lynch Award for Inherited Pancreas Diseases 2018[36]
  • Member of the Academia Europaea 2019[10]

Books (selection)

  1. Neoptolemos JP (Ed). Cancer of the Pancreas.Clinical Gastroenterology, London, Baillière Tindall, Vol 4, No 4 1990[50]
  2. Lemoine N, Cooke T, Neoptolemos JP (Eds). Cancer: A Molecular Approach. Oxford, Blackwell Scientific, 1993 (pp 383)[51]
  3. Neoptolemos JP, Lemoine N (Eds). Pancreatic Cancer: Molecular & Clinical Advances. Oxford, Blackwell Scientific 1996[52]
  4. Beger HG, Warshaw A, Carr-Locke DL, Russell RCG, Buchler M, Neoptolemos JP, Saar M. (Eds). The Pancreas (Two Volumes). Boston, Blackwell Scientific 1998 (pp 1644)[53]
  5. Neoptolemos JP (Ed.). Acute Pancreatitis. Clinical Gastroenterology, London, Bailière Tindall 1999; Vol. 13, No. 2 (pp 152)[54]
  6. Gress TM, Neoptolemos JP, Lemoine NR, Real FX (Eds). Exocrine pancreas cancer. The European Pancreatic Cancer-Research Cooperative (PC-RC). Felsenstein CCCP, Hannover. 2005 (pp 531)[55]
  7. Neoptolemos JP and Bhutani MS. Fast Facts. Pancreas and Biliary Tree. Health Press Abingdon. 2006 (pp127)[56]
  8. Neoptolemos JP and Ghaneh P (Eds). Cancer of the Pancreas. Best Practice & Research in Clinical Gastroenterology. London, Baillière Tindall[57]
  9. Beger HG, Warshaw A, Büchler M, Kozarek R, Lerch M, Neoptolemos JP, Shiratori K, Whitcomb D. (Eds). The Pancreas, Second Edition. Blackwell Publishing, Massachusetts, US, 2008 (pp 1006)[58]
  10. Neoptolemos JP, Urrutia R, Abbruzzese JL, Büchler MW (Eds). Pancreatic Cancer. Springer, New York, 2010. Two Volumes (pp1335)[59]
  11. HG Beger HG, Nakao A, Neoptolemos JP, Peng SY, Sarr MG (Eds). Pancreatic Cancer, Cystic Neoplasms and Endocrine Tumors: Diagnosis and Management.Wiley Blackwell Publishers. 2018 (pp 436)[60]
  12. Beger HG, Warshaw A, Hruban R, Büchler M, Lerch M, Neoptolemos JP, Tooru Shimosegawa, Whitcomb D. (Eds). The Pancreas, Third Edition. Blackwell Publishing, Massachusetts, US, 2018 (pp 1173)[61]
  13. Neoptolemos JP, Urrutia R, Abbruzzese JL, Büchler MW (Eds). Pancreatic Cancer. Springer, New York. Second Edition. 2018. Three Volumes (pp 1642)[62]
  14. Beger HG, Warshaw A, Hruban R, Büchler M, Lerch M, Neoptolemos JP, Tooru Shimosegawa, Whitcomb D. (Eds). The Pancreas, Third Edition. The Pancreas: An Integrated Textbook of Basic Science. Chinese Edition. John Wiley & Sons Limited Chichester, West Sussex, United Kingdom. PO19 8SQ. ISBN 978-1-119-18839-1. 2019[61]

References

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  11. ^ Neoptolemos, John P.; Heagerty, A. M.; Nicholson, M.; James, R. F. L.; Clayton, H.; Bell, P. R. F. (1987). "Inadequacy Of Oleic Acid In Erythrocytes As A Marker Of Malignancies". British Medical Journal (Clinical Research Edition). 294 (6580): 1157–1158. ISSN 0267-0623. JSTOR 29526898.
  12. ^ Neoptolemos, John P.; Lloyd, David M.; Carr-Locke, David L. (1984). "Diagnosing Gall Bladder Disease". British Medical Journal (Clinical Research Edition). 289 (6437): 108. doi:10.1136/bmj.289.6437.108-a. ISSN 0267-0623. JSTOR 29515843. PMC 1441925. PMID 6428671.
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  14. ^ Neoptolemos, J. P.; Dunn, J. A.; Stocken, D. D.; Almond, J.; Link, K.; Beger, H.; Bassi, C.; Falconi, M.; Pederzoli, P.; Dervenis, C.; Fernandez-Cruz, L.; Lacaine, F.; Pap, A.; Spooner, D.; Kerr, D. J.; Friess, H.; Büchler, M. W. (10 November 2001). "Adjuvant chemoradiotherapy and chemotherapy in resectable pancreatic cancer: a randomised controlled trial". The Lancet. 358 (9293): 1576–1585. doi:10.1016/S0140-6736(01)06651-X. PMID 11716884. S2CID 23803289.
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  17. ^ Raraty, Michael; Ward, Jeremy; Erdemli, Gul; Vaillant, Camille; Neoptolemos, John P.; Sutton, Robert; Petersen, Ole H. (2000). "Calcium-Dependent Enzyme Activation and Vacuole Formation in the Apical Granular Region of Pancreatic Acinar Cells". Proceedings of the National Academy of Sciences of the United States of America. 97 (24): 13126–13131. Bibcode:2000PNAS...9713126R. doi:10.1073/pnas.97.24.13126. ISSN 0027-8424. JSTOR 123666. PMC 27189. PMID 11087863.
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  32. ^ Goebell, Harald; Ammann, Rudolf; Creutzfeldt, Werner (May 2005). "History of the European Pancreatic Club: The First 40 Years 1965-2005". Pancreatology. 5 (1): 1–15. doi:10.1159/000086210. PMID 15942268. S2CID 44551677.
  33. ^ Uhl, Waldemar; Warshaw, Andrew; Imrie, Clement; Bassi, Claudio; McKay, Colin J.; Lankisch, Paul G.; Carter, Ross; Magno, Eugene Di; Banks, Peter A.; Whitcomb, David C.; Dervenis, Christos (January 2002). "IAP Guidelines for the surgical management of acute pancreatitis". Pancreatology. 2 (6): 565–573. doi:10.1159/000067684. PMID 12435871.
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  39. ^ Neoptolemos, John P.; Stocken, Deborah D.; Bassi, Claudio; Ghaneh, Paula; Cunningham, David; Goldstein, David; Padbury, Robert; Moore, Malcolm J.; Gallinger, Steven; Mariette, Christophe; Wente, Moritz N.; Izbicki, Jakob R.; Friess, Helmut; Lerch, Markus M.; Dervenis, Christos; Oláh, Attila; Butturini, Giovanni; Doi, Ryuichiro; Lind, Pehr A.; Smith, David; Valle, Juan W.; Palmer, Daniel H.; Buckels, John A.; Thompson, Joyce; McKay, Colin J.; Rawcliffe, Charlotte L.; Büchler, Markus W.; European Study Group for Pancreatic Cancer, for the (8 September 2010). "Adjuvant Chemotherapy With Fluorouracil Plus Folinic Acid vs Gemcitabine Following Pancreatic Cancer Resection: A Randomized Controlled Trial". JAMA. 304 (10): 1073–1081. doi:10.1001/jama.2010.1275. PMID 20823433.
  40. ^ Neoptolemos, John P.; Moore, Malcolm J.; Cox, Trevor F.; Valle, Juan W.; Palmer, Daniel H.; McDonald, Alexander C.; Carter, Ross; Tebbutt, Niall C.; Dervenis, Christos; Smith, David; Glimelius, Bengt; Charnley, Richard M.; Lacaine, François; Scarfe, Andrew G.; Middleton, Mark R.; Anthoney, Alan; Ghaneh, Paula; Halloran, Christopher M.; Lerch, Markus M.; Oláh, Attila; Rawcliffe, Charlotte L.; Verbeke, Caroline S.; Campbell, Fiona; Büchler, Markus W.; European Study Group for Pancreatic Cancer, for the (11 July 2012). "Effect of Adjuvant Chemotherapy With Fluorouracil Plus Folinic Acid or Gemcitabine vs Observation on Survival in Patients With Resected Periampullary Adenocarcinoma: The ESPAC-3 Periampullary Cancer Randomized Trial". JAMA. 308 (2): 147–156. doi:10.1001/jama.2012.7352. PMID 22782416.
  41. ^ Neoptolemos, John P; Palmer, Daniel H; Ghaneh, Paula; Psarelli, Eftychia E; Valle, Juan W; Halloran, Christopher M; Faluyi, Olusola; O'Reilly, Derek A; Cunningham, David; Wadsley, Jonathan; Darby, Suzanne; Meyer, Tim; Gillmore, Roopinder; Anthoney, Alan; Lind, Pehr; Glimelius, Bengt; Falk, Stephen; Izbicki, Jakob R; Middleton, Gary William; Cummins, Sebastian; Ross, Paul J; Wasan, Harpreet; McDonald, Alec; Crosby, Tom; Ma, Yuk Ting; Patel, Kinnari; Sherriff, David; Soomal, Rubin; Borg, David; Sothi, Sharmila; Hammel, Pascal; Hackert, Thilo; Jackson, Richard; Büchler, Markus W (March 2017). "Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial". The Lancet. 389 (10073): 1011–1024. doi:10.1016/S0140-6736(16)32409-6. PMID 28129987. S2CID 4551532.
  42. ^ Neoptolemos, John P.; Stocken, Deborah D.; Friess, Helmut; Bassi, Claudio; Dunn, Janet A.; Hickey, Helen; Beger, Hans; Fernandez-Cruz, Laureano; Dervenis, Christos; Lacaine, François; Falconi, Massimo; Pederzoli, Paolo; Pap, Akos; Spooner, David; Kerr, David J.; Büchler, Markus W. (18 March 2004). "A Randomized Trial of Chemoradiotherapy and Chemotherapy after Resection of Pancreatic Cancer". New England Journal of Medicine. 350 (12): 1200–1210. doi:10.1056/NEJMoa032295. PMID 15028824.
  43. ^ Gottlieb, Scott (2004). "Resectable pancreatic cancer needs surgery, then chemotherapy". BMJ: British Medical Journal. 328 (7441): 661. doi:10.1136/bmj.328.7441.661-a. ISSN 0959-8138. JSTOR 41707160. PMC 381249.
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  47. ^ Bassi, Claudio; Dervenis, Christos; Butturini, Giovanni; Fingerhut, Abe; Yeo, Charles; Izbicki, Jakob; Neoptolemos, John; Sarr, Michael; Traverso, William; Buchler, Marcus (July 2005). "Postoperative pancreatic fistula: An international study group (ISGPF) definition". Surgery. 138 (1): 8–13. doi:10.1016/j.surg.2005.05.001. PMID 16003309.
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  51. ^ Cancer : a molecular approach. Nicholas R. Lemoine, John Neoptolemos, T. Cooke. Oxford: Blackwell Scientific Publications. 1994. ISBN 0-632-03511-0. OCLC 27727126.{{cite book}}: CS1 maint: others (link)
  52. ^ Schein, M (2005-12-06). "Pancreatic cancer. Molecular and clinical advances. J. P. Neoptolemos and N. R. Lemoine (eds). 250 × 775 mm. Pp. 346. Illustrated. 1995. Oxford: Blackwell Science. £59.50". British Journal of Surgery. 83 (6): 876. doi:10.1002/bjs.1800830657. ISSN 0007-1323.
  53. ^ The pancreas. H. G. Beger. Oxford: Blackwell Science. 1998. ISBN 0-86542-420-9. OCLC 36352744.{{cite book}}: CS1 maint: others (link)
  54. ^ Neoptolemos, John P (1999). Acute Pancreatitis, Bailliere's best practice & research. Clinical gastroenterology. London: Bailliere Tindall. p. 152.
  55. ^ Exocrine pancreas cancer the European Pancreatic Cancer-Research Cooperative (EPC-RC). Thomas Mathias Gress. Hannover. 2005. ISBN 978-3-00-016372-2. OCLC 181519963.{{cite book}}: CS1 maint: location missing publisher (link) CS1 maint: others (link)
  56. ^ Neoptolemos, John P. (2006). Diseases of the pancreas and biliary tract. Manoop S. Bhutani. Abingdon: Health Press. ISBN 978-1-905832-22-4. OCLC 746746637.
  57. ^ "Best Practice & Research Clinical Gastroenterology | Pancreatic Cancer | ScienceDirect.com by Elsevier". www.sciencedirect.com. Retrieved 2023-10-18.
  58. ^ The pancreas : an integrated textbook of basic science, medicine, and surgery. H. G. Beger (2 ed.). Malden, Mass.: Blackwell Pub. 2008. ISBN 978-1-4443-0012-3. OCLC 352835994.{{cite book}}: CS1 maint: others (link)
  59. ^ Pancreatic cancer. John Neoptolemos, Raul Urrutia, James L. Abbruzzese, Markus Büchler (1 ed.). New York, NY. 2018. ISBN 978-1-4939-7193-0. OCLC 1031374838.{{cite book}}: CS1 maint: location missing publisher (link) CS1 maint: others (link)
  60. ^ Pancreatic cancer, cystic neoplasms and endocrine tumors : diagnosis and management. H. G. Beger, Akimasa Nakao, John Neoptolemos, Shu You Peng, Michael G. Sarr. Chichester, West Sussex. 2016. ISBN 978-1-118-30783-0. OCLC 898433581.{{cite book}}: CS1 maint: location missing publisher (link) CS1 maint: others (link)
  61. ^ a b The pancreas : an integrated textbook of basic science, medicine, and surgery. H. G. Beger (3 ed.). Wiley. 2018. ISBN 978-1-119-18841-4. OCLC 1065547789.{{cite book}}: CS1 maint: others (link)
  62. ^ Pancreatic cancer. John Neoptolemos, Raul Urrutia, James L. Abbruzzese, Markus Büchler (2 ed.). New York, NY. 2018. ISBN 978-1-4939-7193-0. OCLC 1031374838.{{cite book}}: CS1 maint: location missing publisher (link) CS1 maint: others (link)