Jean-Paul Behr

Jean-Paul Behr, member of the French Académie des sciences

Jean-Paul Behr (born 29 June 1947) is a French chemist, elected member of the French Academy of Sciences (since December 2008).[1]

Research director at the CNRS, he is known for his work in the field of nucleic acid vectorization.

Training and career

• 1969 Engineer ENS Chimie de Strasbourg
• 1973 Doctor of Science
• 1974- Research fellow, then research director at the CNRS
• 1989- Director of the Genetic Chemistry Laboratory at the University of Strasbourg

Scientific activities

Jean-Paul Behr has spent most of his career at the University of Strasbourg. After a doctorate in physical organic chemistry under the supervision of Jean-Marie Lehn (1973) followed by a postdoctoral internship in England, he founded the Genetic Chemistry Laboratory at the Faculty of Pharmacy in Strasbourg. His research there focused mainly on the development of molecules capable of encapsulating DNA and transporting it inside living cells. Jean-Paul Behr developed the first effective lipid vectors,[2][3] then polymeric,[4] which were marketed under the names TransfectamTM, LipofectamineTM and jetPEITM. These vectors are widely used as transfection agents for animal cells in culture, but also as drug-gene carriers in clinical gene therapy trials. To this end, he founded two biotechnology companies, Eurothéra[5] (1994–97) and Polyplus-transfection[6] (2001).

Awards and honours

•    Research & Sharing Prize "Gene Therapy" (1992)
•    CNRS Silver Medal (1998)[7]
•    Paul Ehrlich Prize, Society of Therapeutic Chemistry (2000)[8]
•    Grand Prize founded by the State of the French Academy of Sciences (2000)
•    Biotech Award of the International Pharmaceutical Federation (2003)

References

1. "Académie des sciences".
2. Behr, J.P., « DNA strongly binds to micelles and vesicles containing lipopolyamines or lipointercalants », Tetrahedron Lett, 1986. 27, p. 5861-5864
3. Behr, J.P., « Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine- coated DNA », Proc Natl Acad Sci U S A, 1989. 86 (18), p. 6982-6986
4. Boussif, O, « A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine », Proc Natl Acad Sci U S A,, 1995. 92 (16), p. 7297-7301
5. "Eurothéra". L'express. 9 March 1995.
6. "Polyplus transfection". 22 December 2015. Archived from the original on 12 February 2019. Retrieved 11 October 2019.
7. CNRS. "Les quinze lauréats de la Médaille d'argent du CNRS 1998". cnrs.fr. Archived from the original on 20 July 2014. Retrieved 28 February 2014.
8. "Société de Chimie Thérapeutique". sct.asso.fr. Archived from the original on 2016-03-03.

External links

•    [1] [archive]
•    Biography of the Academy of Sciences. http://www.academie-sciences.fr/fr/Liste-des-membres-de-l-Academie-des-sciences-/-B/jean-paul-behr.html
•    Towards artificial viruses. https://www.lemonde.fr/savoirs-et-connaissances/article/2002/10/21/jean-paul-behr-vers-des-virus-artificiels_295032_3328.html
•    The drug revolution of the future. http://sante.lefigaro.fr/actualite/2012/03/16/17774-revolution-medicaments-futur