Jentsch joined the University of California, Los Angeles in 2001.[3] He was promoted to Associate Professor in 2007, and Associate Director of the Brain Research Institute and Professor in 2009. In 2009 Jentsch woke up to find that his car had been firebombed by animal rights activists.[4] The firebombing was one of a series of attacks against UCLA researchers, criticising Jentsch's use of animals in his research on schizophrenia.[4][5] The following summer Jentsch was on the receiving end of several violent threats from Camille Marino, who told Jentsch that the thought of his death amused her "immensely".[6] Jentsch founded UCLA Pro-Test, a group that looked to take on the alleged misinformation shared by animal rights activists and tackle violent extremism.[7][8]
Jentsch was made Empire Innovation Professor of Psychology at Binghamton University in 2015. His research looks to establish the neural and genetic mechanisms that underpin alcohol and drug addiction.[9]
At Binghamton Jentsch was awarded a $11,700,000 grant from the National Institute on Drug Abuse to investigate cocaine addiction, and the neural pathways that can result in someone becoming addicted.[10] Jentsch is interested in identifying the genes that can predispose people to drug addiction, as this may be able to inform life-saving interventions.[10][11]
Jentsch, J. D.; Taylor, J. R. (October 1, 1999). "Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli". Psychopharmacology. 146 (4): 373–390. doi:10.1007/PL00005483. ISSN1432-2072. PMID10550488. S2CID23450515.
Jentsch is openly gay and is part of the organisation 500 Queer Scientists.[16] He uses social media including Twitter to share his research and experiences as a scientist.[17]