Ivar MendezOC[1] is a Canadian neurosurgeon and neuroscientist who is a professor of surgery at the University of Saskatchewan. He is known for his work in cell transplantation for Parkinson's disease and the use of remote presence robotics in neurosurgery and primary health care. In December 2022, Mendez was appointed an officer of the Order of Canada for his pioneering work in the use of remote telemedicine and robotics to revolutionize the delivery of health and patient care.[2] Dr. Mendez is the Director of the Virtual Health Hub.[3]
Mendez served as the F.H. Wigmore Professor[4] and Provincial Head of the Department of Surgery at the University of Saskatchewan and the Saskatchewan Health Authority from 2013 to 2022 for the Province of Saskatchewan. He also holds an appointment at the Department of Psychology and Neuroscience at Dalhousie University and he is one of the founders of the Brain Repair Centre.[5] He is also the president and founder of the Ivar Mendez International Foundation[6] that provides health and educational assistance to children in the Bolivian Andes. Mendez is a photographer and sculptor[7] and has published four books of photography.
Biography
Mendez was born in La Paz, Bolivia and immigrated with his family to Canada as a teenager. He obtained a BSc degree from the University of Toronto and then an M.D. from the University of Western Ontario (UWO). He did a neurosurgical residency training in London, and was certified in Neurosurgery from the Royal College of Physician and Surgeons of Canada in 1994 and from the American Board of Neurological Surgery[8] in 1996. He became a fellow of the American College of Surgeons in 1998 and became a member of the College Board of Governors[9] in 2015. His interest in regenerative medicine led him to obtain a PhD in Anatomy and Neurobiology from the UWO his PhD thesis was on "Neurotransmitter Interactions in Nigral Grafts".[10] He did a postdoctoral fellowship at the University of Lund in Sweden under the supervision of Anders Björklund.[11] In 2014, Saint Mary's University (Halifax) in Nova Scotia awarded Mendez a Doctor of Science (honoris causa) degree for his contribution to Neuroscience and he was inducted a Fellow to the Canadian Academy of Health Sciences.[citation needed] In 2016, Mendez received the Government of Canada Public Service Award of Excellence for the use of remote presence robotic technology to improve healthcare in the Canadian North.[citation needed] In December 2022, Mendez was appointed an officer of the Order of Canada for his pioneering work in the use of remote telemedicine and robotics to revolutionize the delivery of health and patient care in Canada and worldwide.[2] Dr. Mendez is the Director of the Virtual Health Hub.[3]
Scientific contributions
He pioneered the technique of multiple grafts to restore dopamine input to the parkinsonian mammalian brain.[12][13] This technique was translated into clinical trials in patients with Parkinson's disease and showed long-term survival of those grafts.[14][15][16][17] He also pioneered the use of Glial Derived Neurotrophic Factor (GDNF) in combination with fetal cells in humans.[18][19][20] Mendez invented a transplantation delivery system to inject cells into the human brain.[21] With his team, he performed the first long-distance brain surgery robotic telementoring in the world by using a robotic arm to mentor neurosurgeons located 400 km away.
[22] He is also pioneering the use of remote presence devices to deliver health care in remote locations.[23][24][25]
In 2015, Mendez and his team printed the first 3D brain for planning deep brain stimulation surgery.[26][27][28][29][30] Research in 3D brain printing led in 2016 to the development of a virtual reality (VR) brain for medical education and surgical planning applications.[31][32][33] In 2020, Dr. Mendez and his remote presence technology team pioneered the use of telerobotic ultrasonography for abdominal and obstetric sonography.[34][35] This technology was used to provide prenatal ultrasound to pregnant women living in COVID-19 outbreak communities.[36]
Inventions
Neural transplantation delivery system: Canadian Patent #2,281,007[37] and US Patent #7,137,969[38]
Injection delivery system: US Patent #8,753,314[39] and US patent #9,067,028[40]
Humanitarian contributions
Mendez has established a Canadian charitable organization, the Ivar Mendez International Foundation,[6] to provide nutrition, dental care and art program to children in remote locations of the Bolivian Andes.[41]
Royal College Medal Award - Medalist in Surgery[50]
Artistic endeavours
He has published four books of photography [51] and has had several exhibitions of his photography and sculpture [52] In October 2003 He sculpted a bust of Canadian NeurosurgeonDr. Charles Drake was installed outside the front entrance of University Hospital in London, Ontario where Drake practiced medicine. The statue was unveiled by American Actress and Singer Della Reese whose life was saved by Drake following an Aneurysm in October 1979.[53]
Published books
Bolivia. Mendez, I. ISBN0-920427-64-2. Glen Margaret Publishing 2006.
Cooper O, Astradsson A, Hallett P, Robertson H, Mendez I, Isacson O (2009). "Lack of functional relevance of isolated cell damage in transplants of Parkinson's disease patients". Journal of Neurology. 256 (Suppl 3): 310–316. CiteSeerX10.1.1.407.8657. doi:10.1007/s00415-009-5242-z. PMID19711122. S2CID16653812.
Mendez I, Song M, Chiasson P, Bustamante L (2013). "Point-of-Care Programming for Neuromodulation: A Feasibility Study Using Remote Presence". Neurosurgery. 72 (1): 99–108. doi:10.1227/NEU.0b013e318276b5b2. PMID23096417.
Adams, S. J.; Penz, E.; Imeah, B.; Burbridge, B.; Obaid, H.; Babyn, P.; Mendez, I (January 2023). "Economic Evaluation of Telerobotic Ultrasound Technology to Remotely Provide Ultrasound Services in Rural and Remote Communities". Journal of Ultrasound in Medicine. 42 (1): 109–123. doi:10.1002/jum.16070. PMID35906950.
^Mendez I, Elisevich K, Flumerfelt B (June 1991). "Dopaminergic innervation of substance P-containing striatal neurons by fetal nigral grafts: an ultrastructural double-labeling immunocytochemical study". The Journal of Comparative Neurology. 308 (1): 66–78. doi:10.1002/cne.903080107. PMID1714923. S2CID34912060..
^Mendez I, Hong M (December 5, 1997). "Reconstruction of the striato-nigro-striatal circuitry by simultaneous double dopaminergic grafts: a tracer study using fluorogold and horse radish peroxidase". Brain Research. 778 (1): 194–205. doi:10.1016/s0006-8993(97)01055-x. PMID9462892. S2CID26078626.
^Mendez I, Dagher A, Hong M, Gaudet P, Weerasinghe S, McAlister V, King D, Desrosiers J, Darvesh S, Acorn T, Robertson H (2002). "Simultaneous intrastriatal and intranigral fetal dopaminergic grafts in patients with Parkinson's disease". Journal of Neurosurgery. 96 (3): 589–596. doi:10.3171/jns.2002.96.3.0589. PMID11883846.
^Apostolides C, Sanford E, Hong M, Mendez I (March 1998). "Glial cell line--derived neurotrophic factor improves intrastriatal graft survival of stored dopaminergic cells". Neuroscience. 83 (2): 363–372. doi:10.1016/s0306-4522(97)00369-2. PMID9460746. S2CID29928233.
^Mehta V, Hong M, Spears J, Mendez I (June 1998). "Enhancement of graft survival and sensorimotor behavioral recovery in rats undergoing transplantation with dopaminergic cells exposed to glial cell line-derived neurotrophic factor". Journal of Neurosurgery. 88 (6): 1088–1095. doi:10.3171/jns.1998.88.6.1088. PMID9609305. S2CID7481810.
^Mendez I, Dagher A, Hong M, Hebb A, Gaudet P, Law A, Weerasinghe S, King D, Desrosiers J, Darvesh S, Acorn T, Robertson H (May 2000). "Exposure of human fetal nigral tissue to glial cell line-derived neurotrophic factor enhances survival in two patients with Parkinson's disease". Journal of Neurosurgery. 92 (5): 863–869. doi:10.3171/jns.2000.92.5.0863. PMID10794303.
^Mendez I, Hong M, Smith S, Dagher A, Desrosiers J (March 2000). "A neural transplantation cannula and microinjector system: experimental and clinical experience". Journal of Neurosurgery. 92 (3): 493–499. doi:10.3171/jns.2000.92.3.0493. PMID10701543. S2CID21561353.
^Mendez I, Song M, Chiasson P, Bustamante L (January 2013). "Point-of-Care Programming for Neuromodulation: A Feasibility Study Using Remote Presence". Neurosurgery. 72 (1): 99–108. doi:10.1227/NEU.0b013e318276b5b2. PMID23096417.
