Iselin's Geschichte der Menschheit ("History of Humanity") was the first fully-fledged history of humanity in German. The Geschichte der Menschheit was provoked by what Iselin conceived as Montesquieu's climatological determinism and Rousseau's critique of progress and at the same time inspired by exponents of the Scottish Enlightenment such as Lord Kames. Iselin's pen-friend Moses Mendelssohn in his review of the first edition of 1764, lauded Iselin as one of the best German prose writers.
^ abZurbuchen, Simone (2006), "Iselin, Isaak", in Haakonssen, Knud (ed.), The Cambridge History of Eighteenth-Century Philosophy, vol. 2, Cambridge University Press, p. 1186
Béla Kapossy, Iselin contra Rousseau: Sociable Patriotism and the History of Mankind (Basel, Switzerland: Schwabe, 2006) (Schwabe Philosophica, 9).
Andreas Urs Sommer, Geschichte als Trost. Isaak Iselins Geschichtsphilosophie (Basel: Schwabe, 2002) (= Schwabe Horizonte) (ISBN3-7965-1940-7).
Lucas Marco Gisi / Wolfgang Rother (ed.), Isaak Iselin und die Geschichtsphilosophie der europäischen Aufklärung (Basel: Schwabe, 2011).