International Society for Extracellular Vesicles

International Society for Extracellular Vesicles
Founded2011
TypeProfessional organization
FocusExtracellular vesicles
Area served
Worldwide
MethodConferences, publications, education
Members>2000
Key people
Kenneth W. Witwer (president]
Edit Buzás (immediate past-president)
Clotilde Théry (past-president and founding secretary general)
Andrew Hill (past-president)
Jan Lötvall (founding president)
Websiteisev.org

The International Society for Extracellular Vesicles (ISEV) is an international scientific organization that focuses on advancing global extracellular vesicle (EV) research.[1] These membrane-bound particles are released from all known cells and include exosomes, ectosomes, exophers, oncosomes, and more. Established in 2011, the society is a nonprofit organization. It is governed by an executive committee. The current president is Kenneth Witwer. Previous presidents were Edit Buzás (2022-2024), Clotilde Théry (2018-2022), Andrew Hill (2016-2018) and founding president Jan Lötvall (2011-2016). The society's journals are the Journal of Extracellular Vesicles and the Journal of Extracellular Biology.[2] ISEV also publishes the international consensus guidelines for EV studies, the "Minimal information for studies of EVs" (MISEV).[3][4]

ISEV has several committees (Meetings and Programs, Science and Journals, Rigor and Standardization, Education, Translation, Regulation, and Advocacy Committee, and Communications and Membership) focused on advancing research and promoting awareness in the EVs. Each committee has specific roles and goals.

Meetings

As part of its mission to promote scientific research and education, the society hosts annual meetings and educational event as well as numerous workshops on defined EV-related topics. The society also co-sponsors or endorses related events.

Annual meeting Location
ISEV2024 Melbourne, Australia
ISEV2023 Seattle, USA
ISEV2022 Lyon, France
ISEV2021 Virtual Meeting
ISEV2020 Virtual Meeting
ISEV2019 Kyoto, Japan
ISEV2018 Barcelona, Spain
ISEV2017 Toronto, Canada
ISEV2016 Rotterdam, Netherlands
ISEV2015 Washington DC, USA
ISEV2014 Rotterdam, Netherlands
ISEV2013 Boston, USA
ISEV2012 Gothenburg, Sweden

Workshops and scientific seminars

ISEV workshops began with a meeting on extracellular RNA (New York City, 2012),[5][6][7] and continue to include one to two meetings per year. During widespread restrictions on in-person meetings during the COVID-19 pandemic, ISEV introduced the "Extracellular Vesicle Club," a weekly virtual event featuring presentations and moderated discussion of scientific publications.[8]

Topic Location Year
Blood EVs South Korea September 2024
Large Extracellular Vesicles United States March 2024
EV-based Biomarkers Denmark October 2023
Workshop by EV-TRACK Task Force Virtual March 2023
The second Urine EV Task Force Virtual Symposium on Urinary Extracellular Vesicles Virtual February 2023
QuantitatEVs: Multiscale analyses, from bulk to single vesicle Rome and Milan January-February 2023
Blood EVs: an ISEV Workshop Finland September 2022
massivEVs Workshop Italy/Virtually October 2021
Infectious Diseases Meeting Virtual January 2021
EV Imaging in Vivo France September 2020
EVs in Immunology Buenos Aires March 2020
Open, Reproducible and Standardized EV Research Belgium December 2019
EV-based Clinical Theranostics China November 2018
Membranes and EVs Workshop United States March 2018
Extracellular Vesicles as Biomarkers of Disease United Kingdom December 2017
Diet, Environment and Extracellular Vesicles Australia January 2017
Cross-Organism Communication by Extracellular Vesicles: Hosts, Microbes, Parasites Brazil November 2016
Research Seminar: EV-associated RNA: Is there a purpose? Netherlands September 2015
ISEV Workshop on Isolation and Characterization of Extracellular Vesicles Hungary October 2013
ISEV RNA Workshop United States October 2012

Endorsed or co-sponsored events

The society has directly or indirectly supported EV-related events around the world. These include meetings of the UK, French, and Spanish and Portuguese EV Societies (GEIVEX), a course of the European Molecular Biology Laboratory, Keystone Symposia (2016 and 2018),[9] Gordon Research Conferences (2016, 2018, and 2022),[10] a Cold Spring Harbor Asia Meeting (2016),[11] and others.

Journal of Extracellular Vesicles, Journal of Extracellular Biology, and standardization initiatives

To disseminate research in the field, the society established the peer-reviewed open access Journal of Extracellular Vesicles in 2012.[12] The journal was initially published by Co-Action Publishing, by Taylor & Francis from 2016-2020, and by Wiley since 2020. In addition to research and review articles, the journal periodically publishes position papers of the society that are meant to advance standardization efforts.[6][7] In 2014, the Executive Board of Directors published a set of minimal information guidelines for publication of EV studies.[13][14] These requirements, known as "MISEV" or "MISEV2014," mirrored similar initiatives in the fields of microarray (MIAME) and proteomics (MIAPE) analysis, among others. In 2017, the society's board announced its intent to update these requirements with community involvement.[15] The "MISEV2018" requirements were published in 2018 by Clotilde Théry and Kenneth Witwer with input from 380 co-authors.[16] The current consensus guidelines, known as "MISEV2023", were prepared with input from more than 1050 co-authors, using extensive crowdsourcing of expert opinion to build consensus.[4] The corresponding authors are Joshua Welsh, Deborah Goberdhan, Lorraine O'Driscoll, Clotilde Théry and Kenneth Witwer.[3]

In 2021, ISEV founded a second journal, the Journal of Extracellular Biology, focusing on EVs but also other extracellular particles (EPs) and phenomena.[2][17] The editor-in-chief is Andrew Hill.

Education

Among the educational initiatives of the society are massive open online courses (MOOCs), launched in 2016. MOOC 1&II are available through Coursera[18][19] and co-sponsored by the University of Gothenburg, Pohang University of Science and Technology, and the University of California, Irvine.[20] MOOC III is available on YouTube

Student Network on Extracellular Vesicles

In 2020, the Student Network on Extracellular Vesicles (SNEV) was founded as a virtual network for early-career researchers in EV research. SNEV’s activities include organizing online scientific talks, a monthly newsletter, industry talks and informal meet-and-greets (coffee catch ups). SNEV has organized two virtual conferences, one in 2021 and the second in 2023. Since 2024, SNEV has become the official early career within ISEV.

[TD1]Link to Student Network on Extracellular Vesicles (wordpress.com)

References

  1. ^ "Better living through mitochondrial derived vesicles". MedicalXpress.
  2. ^ a b Hill AF, Sahoo S (March 2022). "Launching the Journal of Extracellular Biology (J Ex Bio) – A new journal from the International Society for Extracellular Vesicles (ISEV)". Journal of Extracellular Biology. 1 (1). e19. doi:10.1002/jex2.19. PMC 11080626. S2CID 247483494.
  3. ^ a b Welsh JA, et al. (2024). "Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches". J. Extracell. Vesicles. 13 (2): e12404. doi:10.1002/jev2.12404. PMC 10850029. PMID 38326288.
  4. ^ a b Welsh JA, et al. (2024). "MISEV2023: An updated guide to EV research and applications". J. Extracell. Vesicles. 13 (2): 12416. doi:10.1002/jev2.12416. PMC 10891433. PMID 38400602.
  5. ^ "RNA Workshop". Archived from the original on 2014-05-30. Retrieved 2014-04-29.
  6. ^ a b Witwer, K. W.; Buzás, E.I.; Bemis, L.T.; Bora, A.; Lässer, C.; Lötvall, J.; Nolte-'t Hoen, E.N.; Piper, M.G.; Sivaraman, S.; Skog, J.; Théry, C.; Wauben, M.H.; Hochberg, F. (2013). "Standardization of sample collection, isolation and analysis methods in extracellular vesicle research". Journal of Extracellular Vesicles. 2: 20360. doi:10.3402/jev.v2i0.20360. PMC 3760646. PMID 24009894.
  7. ^ a b Hill, A.F.; Pegtel, D.M.; Lambertz, U.; Leonardi, T.; O'Driscoll, L.; Pluchino, S.; Ter-Ovanesyan, D.; Nolte-'t Hoen, E.N. (2013). "ISEV position paper: Extracellular vesicle RNA analysis and bioinformatics". Journal of Extracellular Vesicles. 2: 22859. doi:10.3402/jev.v2i0.22859. PMC 3873759. PMID 24376909.
  8. ^ "International Society for Extracellular Vesicles Launches EV Club". WFMZ-TV News Allentown. 20 April 2021. Retrieved 22 April 2021.
  9. ^ "Scientific Conferences on Biomedical and Life Science Topics". Keystone Symposia.
  10. ^ "2016 Extracellular Vesicles Conference GRC". Gordon Research Conferences.
  11. ^ "CSH Asia 2016 Conference on Biology & Function of Extracellular Vesicles: Exosomes, Microvesicles & Beyond". Cold Spring Harbor Asia.
  12. ^ "Journal information". Journal of Extracellular Vesicles.
  13. ^ Lötvall, J.; Hill, A.F.; Hochberg, F.; Buzás, E.I.; Di Vizio, D.; Gardiner, C.; Gho, Y.S.; Kurochkin, I.V.; Mathivanan, S.; Quesenberry, P.; Sahoo, S.; Tahara, H.; Wauben, M.H.; Witwer, K.W.; Théry, C. (2014). "Minimal experimental requirements for definition of extracellular vesicles and their functions: A position statement from the International Society for Extracellular Vesicles". Journal of Extracellular Vesicles. 3: 26913. doi:10.3402/jev.v3.26913. PMC 4275645. PMID 25536934.
  14. ^ "Enhanced Analysis of Extracellular Vesicles with Imaging Flow Cytometry". Archived from the original on 2015-12-08. Retrieved 2015-11-28.
  15. ^ Witwer, Kenneth W.; Soekmadji, Carolina; Hill, Andrew F.; Wauben, Marca H.; Buzás, Edit I.; Di Vizio, Dolores; Falcon-Perez, Juan M.; Gardiner, Chris; Hochberg, Fred; Kurochkin, Igor V.; Lötvall, Jan; Mathivanan, Suresh; Nieuwland, Rienk; Sahoo, Susmita; Tahara, Hidetoshi; Torrecilhas, Ana Claudia; Weaver, Alissa M.; Yin, Hang; Zheng, Lei; Gho, Yong Song; Quesenberry, Peter; Théry, Clotilde (2017). "Updating the MISEV minimal requirements for extracellular vesicle studies: building bridges to reproducibility". Journal of Extracellular Vesicles. 6 (1): 1396823. doi:10.1080/20013078.2017.1396823. ISSN 2001-3078. PMC 5698937. PMID 29184626.
  16. ^ Théry, C. (2018). "Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines". Journal of Extracellular Vesicles. 7 (1): 1535750. doi:10.1080/20013078.2018.1535750. PMC 6322352. PMID 30637094.
  17. ^ "Journal of Extracellular Biology (Wiley)".
  18. ^ "Basics of Extracellular Vesicles". Coursera.
  19. ^ "Extracellular Vesicles in Health and Disease".
  20. ^ "Well-Attended Two-Track Education Day Precedes Opening of International Society for Extracellular Vesicles (ISEV 2016) Annual Meeting in Rotterdam May 4-7". BioQuick News.com (Press release). 3 May 2016.