Inositol-polyphosphate 5-phosphatase

Inositol-polyphosphate 5-phosphatase
Identifiers
EC no.	3.1.3.56
CAS no.	106283-14-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

The enzyme inositol-polyphosphate 5-phosphatase (EC 3.1.3.56), systematic name 1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase, catalyses the following reactions:

(1) D-myo-inositol 1,4,5-trisphosphate + H₂O ${\displaystyle \rightleftharpoons }$ myo-inositol 1,4-bisphosphate + phosphate

(2) 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H₂O ${\displaystyle \rightleftharpoons }$ 1D-myo-inositol 1,3,4-trisphosphate + phosphate

Ten mammalian isoforms are known.[1]

Other names of this enzyme include type I inositol-polyphosphate phosphatase, inositol trisphosphate phosphomonoesterase, InsP₃/Ins(1,3,4,5)P₄ 5-phosphatase, inosine triphosphatase, D-myo-inositol 1,4,5-triphosphate 5-phosphatase, D-myo-inositol 1,4,5-trisphosphate 5-phosphatase, L-myo-inositol 1,4,5-trisphosphate-monoesterase, inositol phosphate 5-phosphomonoesterase, inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase, Ins(1,4,5)P₃ 5-phosphataseD-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase, inositol 1,4,5-trisphosphate phosphatase, inositol polyphosphate-5-phosphatase, myo-inositol-1,4,5-trisphosphate 5-phosphatase, inositol-1,4,5-trisphosphate 5-phosphatase.[2][3][4][5]

References

1. Ooms LM, Horan KA, Rahman P, Seaton G, Gurung R, Kethesparan DS, Mitchell CA (2009). "The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease". The Biochemical Journal. 419 ( Pt 1): 29–49. doi:10.1042/BJ20081673. PMID 19272022.
2. Downes CP, Mussat MC, Michell RH (April 1982). "The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane". The Biochemical Journal. 203 (1): 169–77. doi:10.1042/bj2030169. PMC 1158207. PMID 6285891.
3. Erneux C, Lemos M, Verjans B, Vanderhaeghen P, Delvaux A, Dumont JE (May 1989). "Soluble and particulate Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphatase in bovine brain". European Journal of Biochemistry. 181 (2): 317–22. doi:10.1111/j.1432-1033.1989.tb14726.x. PMID 2540972.
4. Woscholski, R.; Parker, P.J. (2000). "Inositol phosphatases: constructive destruction of phosphoinositides and inositol phosphates". In Cockcroft, S. (ed.). Biology of Phosphoinositides. Oxford: Biology of Phosphoinositides. pp. 320–338.
5. Verjans B, De Smedt F, Lecocq R, Vanweyenberg V, Moreau C, Erneux C (May 1994). "Cloning and expression in Escherichia coli of a dog thyroid cDNA encoding a novel inositol 1,4,5-trisphosphate 5-phosphatase". The Biochemical Journal. 300 ( Pt 1): 85–90. doi:10.1042/bj3000085. PMC 1138127. PMID 8198557.

External links

• Inositol-polyphosphate+5-phosphatase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)