Infectious pancreatic necrosis birnavirus Vp4 peptidase

Infectious pancreatic necrosis birnavirus Vp4 peptidase
Identifiers
EC no.3.4.21.115
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
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NCBIproteins

Infectious pancreatic necrosis birnavirus Vp4 peptidase (EC 3.4.21.115, infectious pancreatic necrosis virus protease, IPNV Vp4 protease, IPNV Vp4 peptidase, NS protease, NS-associated protease, Vp4 protease) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

Cleaves the (Ser/Thr)-Xaa-Ala-(Ser/Ala)-Gly motif in the polyprotein NH2-pVP2-VP4-VP3-COOH of infectious pancreatic necrosis virus at the pVP2-VP4 and VP4-VP3 junctions

Infectious pancreatic necrosis virus is a birnavirus that causes an acute, contagious disease in young salmonid fish.

References

  1. ^ Manning DS, Leong JC (November 1990). "Expression in Escherichia coli of the large genomic segment of infectious pancreatic necrosis virus". Virology. 179 (1): 16–25. doi:10.1016/0042-6822(90)90268-v. PMID 2219718.
  2. ^ Petit S, Lejal N, Huet JC, Delmas B (March 2000). "Active residues and viral substrate cleavage sites of the protease of the birnavirus infectious pancreatic necrosis virus". Journal of Virology. 74 (5): 2057–66. doi:10.1128/jvi.74.5.2057-2066.2000. PMC 111686. PMID 10666235.
  3. ^ Dobos, P. (1995). "The molecular biology of infectious pancreatic necrosis virus (IPNV)". Annu. Rev. Fish Dis. 5: 25–54. doi:10.1016/0959-8030(95)00003-8.