Indeterminate cell histiocytosis

Indeterminate cell histiocytosis
Other namesIndeterminate dendritic cell tumor
SpecialtyDermatology

Indeterminate cell histiocytosis (LCH) is an uncommon proliferative illness where the predominant cells have characteristics from both non-Langerhans cell histiocytosis (NLCH) and Langerhans cell histiocytosis (LCH) in terms of morphology and immunophenotypic characteristics.[1] Wood et al. originally described ICH in 1985 as a neoplastic disease arising from dermal indeterminate cells that lack Birbeck granules but are characteristically positive for S-100 and CD1a.[2]

Signs and symptoms

Clinically, ICH is defined by pink to reddish, varying-sized, painless, non-itching papules or nodules that develop on otherwise healthy skin (sparing mucosae). These lesions can appear as a single, distinct group of lesions, or several generalized papules dispersed over the trunk, face, and limbs. They can also show signs of stable disease, remission and recurrence, or spontaneous remission.[3]

Causes

Possible causes include scabies,[4] mosquito bites,[5] and a clonal drive.[6]

Treatment

Treatment include 5% 5-fluorouracil cream, topical pure coal tar, electron beam therapy, phototherapy, and total excision.[7][8]

See also

References

  1. ^ Vener, C.; Soligo, D.; Berti, E.; Gianelli, U.; Servida, F.; Ceretti, E.; Caputo, R.; Passoni, E.; Lambertenghi Deliliers, G. (2007). "Indeterminate cell histiocytosis in association with later occurrence of acute myeloblastic leukaemia". British Journal of Dermatology. 156 (6). Oxford University Press (OUP): 1357–1361. doi:10.1111/j.1365-2133.2007.07880.x. ISSN 0007-0963. PMID 17459045. S2CID 41005413.
  2. ^ WOOD, GARY S.; HU, CHUNG-HONG; BECKSTEAD, JAY H.; TURNER, RODERICK R.; WINKELMANN, R. K. (1985). "The Indeterminate Cell Proliferative Disorder: Report of a Case Manifesting as an Unusual Cutaneous Histiocytosis". The Journal of Dermatologic Surgery and Oncology. 11 (11). Wiley: 1111–1119. doi:10.1111/j.1524-4725.1985.tb01399.x. ISSN 0148-0812. PMID 3902927.
  3. ^ Zerbini, Maria Claudia Nogueira; Sotto, Mirian Nacagami; Campos, Fernando Peixoto Ferraz de; Abdo, Andre Neder Ramires; Pereira, Juliana; Sanches, José Antônio; Martins, Jade Cury (2016). "Indeterminate cell histiocytosis successfully treated with phototherapy". Autopsy and Case Reports. 6 (2). Editora Cubo: 33–38. doi:10.4322/acr.2016.038. ISSN 2236-1960. PMC 4982782. PMID 27547741.
  4. ^ Hashimoto, Ken; Fujiwara, Keiko; Punwaney, Juanita; DiGregorio, Fiorino; Bostrom, Paul; El-Hoshy, Khaled; Aronson, Peter J.; Schoenfeld, Robert J. (2000). "Post-Scabetic Nodules: A Lymphohistiocytic Reaction Rich in Indeterminate Cells". The Journal of Dermatology. 27 (3). Wiley: 181–194. doi:10.1111/j.1346-8138.2000.tb02148.x. ISSN 0385-2407. PMID 10774146. S2CID 23463988.
  5. ^ Mo, Xianglan; Guo, Wenwen; Ye, Hongtao (2015). "Primary Indeterminate Dendritic Cell Tumor of Skin Correlated to Mosquito Bite". Medicine. 94 (34). Ovid Technologies (Wolters Kluwer Health): e1443. doi:10.1097/md.0000000000001443. ISSN 0025-7974. PMC 4602924. PMID 26313805.
  6. ^ Brown, Ryanne A.; Kwong, Bernice Y.; McCalmont, Timothy H.; Ragsdale, Bruce; Ma, Lisa; Cheung, Christine; Rieger, Kerri E.; Arber, Daniel A.; Kim, Jinah (November 12, 2015). "ETV3-NCOA2 in indeterminate cell histiocytosis: clonal translocation supports sui generis". Blood. 126 (20). American Society of Hematology: 2344–2345. doi:10.1182/blood-2015-07-655530. ISSN 0006-4971. PMID 26438513.
  7. ^ Miracco, Clelia; Raffaelli, Miranda; de Santi, Maria; Margherita, M.S; Fimiani, Michele; Tosi, Piero (February 1988). "Solitary cutaneous reticulum cell tumor. Enzyme-immunohistochemical and electron-microscopic analogies with IDRC sarcoma". The American Journal of Dermatopathology. 10 (1): 47–53. doi:10.1097/00000372-198802000-00006. PMID 2845833. Retrieved 24 January 2024.
  8. ^ Berti, Emilio (August 1, 1988). "Unusual Cutaneous Histiocytosis Expressing an Intermediate Immunophenotype Between Langerhans' Cells and Dermal Macrophages". Archives of Dermatology. 124 (8). American Medical Association (AMA): 1250. doi:10.1001/archderm.1988.01670080062020. ISSN 0003-987X. PMID 3401031.

Further reading